PMID: 8997233Dec 1, 1996Paper

Contributions of liver and kidneys to glycerol production and utilization in the dog

The American Journal of Physiology
S F PrevisH Brunengraber

Abstract

The classical concept holds that liver and kidneys are the main sinks of glycerol released by adipose tissue. However, rates of glycerol appearance (Ra) exceed the rate of glycerol delivery to liver and kidneys. We measured the hepatic and renal contributions to glycerol production and utilization in anesthetized dogs that were fasted either overnight or for 24 h after 3 days on a carbohydrate-free diet. Dogs were infused with [2H5]glycerol, and the concentration and 2H enrichment of glycerol were measured across liver and kidney. After a baseline period, either norepinephrine or glucose plus insulin was infused to alter the rate of glycerol production. Our study shows that the production of glycerol by liver and kidneys amounted to 4-9% and 4-7% of the Ra of glycerol, respectively. Uptake of glycerol by liver and kidneys amounted to 26-30 and 10-19% of the Ra of glycerol, respectively. Thus, contrary to the classical concept, the bulk of glycerol utilization occurs in nonhepatic, nonrenal tissues that have very low glycerol kinase activity per gram.

References

Jan 1, 1977·Annual Review of Biochemistry·E C Lin
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Sep 1, 1983·The Journal of Clinical Investigation·K AchesonJ Wahren
Nov 1, 1984·The Journal of Clinical Investigation·K J AchesonE Jéquier
Mar 1, 1996·Journal of Mass Spectrometry : JMS·C A FernandezH Brunengraber
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Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·G Ahlborg, J Wahren

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Citations

Dec 3, 2003·American Journal of Physiology. Endocrinology and Metabolism·Dale S EdgertonAlan D Cherrington
Oct 16, 1999·Hypertension·P F DamianoI J de la Riva
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·M D JensenB R Landau
Apr 12, 2001·Journal of Applied Physiology·Y BurelleF Péronnet

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