Contributions of medial prefrontal cortex to decision making involving risk of punishment

Neuropharmacology
Caitlin A OrsiniBarry Setlow

Abstract

The prefrontal cortex (PFC) plays an important role in several forms of cost-benefit decision making. Its contributions to decision making under risk of explicit punishment, however, are not well understood. A rat model was used to investigate the role of the medial PFC (mPFC) and its monoaminergic innervation in a Risky Decision-making Task (RDT), in which rats chose between a small, "safe" food reward and a large, "risky" food reward accompanied by varying probabilities of mild footshock punishment. Inactivation of mPFC increased choice of the large, risky reward when the punishment probability increased across the session ("ascending RDT"), but decreased choice of the large, risky reward when the punishment probability decreased across the session ("descending RDT"). In contrast, enhancement of monoamine availability via intra-mPFC amphetamine reduced choice of the large, risky reward only in the descending RDT. Systemic administration of amphetamine reduced choice of the large, risky reward in both the ascending and descending RDT; however, this reduction was not attenuated by concurrent mPFC inactivation, indicating that mPFC is not a critical locus of amphetamine's effects on risk taking. These findings suggest that mPFC ...Continue Reading

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Citations

Nov 6, 2018·Behavioural Pharmacology·Shelby L BlaesBarry Setlow
Oct 21, 2018·Cognitive, Affective & Behavioral Neuroscience·Caitlin A OrsiniBarry Setlow
Oct 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mieke van Holstein, Stan B Floresco
Jul 21, 2020·Current Protocols in Neuroscience·Caitlin A Orsini, Nicholas W Simon
Apr 10, 2020·The Australian and New Zealand Journal of Psychiatry·Pierre-François RousseauStéphanie Khalfa
Jan 16, 2020·Biological Psychiatry·Lindsay R HalladayAndrew Holmes
Jun 13, 2020·Behavioural Brain Research·Lucas R GloverAndrew Holmes
Mar 12, 2021·Journal of Neurochemistry·Patrick T PiantadosiAndrew Holmes
Jul 6, 2021·Brain Communications·Dan D JobsonRajesh N Kalaria

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