Contributions of peripheral and central opioid receptors to antinociception in rat muscle pain models

Pharmacology, Biochemistry, and Behavior
Eva Ma SánchezMa Isabel Martín

Abstract

Administration of hypertonic saline (HS) is an accepted model to study muscular pain. HS-induced nociceptive responses were tested in masseter, already described, and in two new pain models of spinally innervated muscles (gastrocnemius and triceps) developed in rats at our laboratory. HS administration in the masseter induced vigorous hindpaw shaking and in the gastrocnemius or triceps, paw withdrawal or flexing. Participation of the central and peripheral opioid receptors in HS-induced pain is compared in these muscles: masseter, innervated by trigeminal nerve, and gastrocnemius and triceps by spinal nerves. Morphine and loperamide were used to reveal peripheral and central components of opioid analgesia. Both agonists reduced HS-induced nociceptive behaviours in the masseter and were antagonised by the opioid antagonist naloxone and by naloxone methiodide, an opioid receptor antagonist that poorly penetrates the blood-brain barrier. Unexpectedly, in the gastrocnemius and triceps, morphine, but not loperamide, decreased the nociceptive behaviour and this effect was only reversed by naloxone. So, peripheral opioid receptors seem to participate in HS-induced masseter pain, whereas only central opioid receptors reduced the nocice...Continue Reading

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Citations

Oct 9, 2012·Peptides·Richard J Bodnar
Oct 22, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R GirónR Abalo
Nov 28, 2012·European Journal of Pharmacology·Carlos B FilhoCristiano R Jesse
Jan 21, 2017·International Immunopharmacology·Ianna Wivianne Fernandes AraújoNorma Maria Barros Benevides
Dec 28, 2016·Muscle & Nerve·Ana BagüésEva M Sánchez-Robles
Dec 21, 2017·Anesthesia and Analgesia·Ana BaguesEva María Sánchez-Robles
Mar 15, 2019·Journal of Neurogastroenterology and Motility·Susana Díaz-RuanoRaquel Abalo
Feb 23, 2012·European Journal of Pain : EJP·E Ma Sánchez RoblesMa I Martín Fontelles
May 23, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Gema VeraRaquel Abalo
Mar 14, 2020·Behavioural Pharmacology·Vicente Martínez, Raquel Abalo
May 22, 2020·Oral Diseases·Qing LiuFang Huang
Jan 21, 2021·Neuroreport·Diogo F S SantosMaria C G Oliveira-Fusaro
Apr 8, 2021·European Journal of Pharmacology·William A GonçalvesThiago R L Romero
May 22, 2021·Frontiers in Neuroscience·Qing LiuFang Huang

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