Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada

BMJ : British Medical Journal
Tara GomesDavid N Juurlink

Abstract

To describe the contributions of prescribed and non-prescribed opioids to opioid related deaths. Population based cohort study. Ontario, Canada, from 1 January 2013 to 31 December 2016. All Ontarians who died of an opioid related cause. Active opioid prescriptions, defined as those with a duration overlapping the date of death, and recent opioid prescriptions, defined as those dispensed in the 30 and 180 days preceding death. Postmortem toxicology results from the Drug and Drug/Alcohol Related Death database were used to characterise deaths on the basis of presence of prescribed and non-prescribed (that is, diverted or illicit) opioids, overall and stratified by year and age. 2833 opioid related deaths occurred. An active opioid prescription on the date of death was relatively common but declined slightly throughout the study period (38.2% (241/631) in 2013 and 32.5% (278/855) in 2016; P for trend=0.03). Older people and women were relatively more likely to have an active opioid prescription at time of death. In 2016, 46% (169/364) of people aged 45-64 had an active opioid prescription compared with only 12% (8/69) among those aged 24 or younger (P for trend<0.001). Similarly, 46% (124/272) of women had an active opioid prescri...Continue Reading

Citations

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