Contributions of the medial temporal lobe to declarative memory retrieval: manipulating the amount of contextual retrieval

Learning & Memory
Indira TendolkarGuillén Fernández

Abstract

We investigated how the hippocampus and its adjacent mediotemporal structures contribute to contextual and noncontextual declarative memory retrieval by manipulating the amount of contextual information across two levels of the same contextual dimension in a source memory task. A first analysis identified medial temporal lobe (MTL) substructures mediating either contextual or noncontextual retrieval. A linearly weighted analysis elucidated which MTL substructures show a gradually increasing neural activity, depending on the amount of contextual information retrieved. A hippocampal engagement was found during both levels of source memory but not during item memory retrieval. The anterior MTL including the perirhinal cortex was only engaged during item memory retrieval by an activity decrease. Only the posterior parahippocampal cortex showed an activation increasing with the amount of contextual information retrieved. If one assumes a roughly linear relationship between the blood-oxygenation level-dependent (BOLD) signal and the associated cognitive process, our results suggest that the posterior parahippocampal cortex is involved in contextual retrieval on the basis of memory strength while the hippocampus processes representati...Continue Reading

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Citations

Jul 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Indira TendolkarGuillén Fernández
Aug 26, 2009·Journal of Cognitive Neuroscience·Rachel A DianaCharan Ranganath
Feb 14, 2016·Cerebral Cortex·Rachel A Diana
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Aug 18, 2021·Brain Topography·Elisabeth KaufmannSoheyl Noachtar

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