Contributions of vascular tone and structure to elastic properties of a medium-sized artery

Hypertension
R WeberD Hayoz

Abstract

Isobaric compliance and distensibility of the radial artery were recently reported to be normal or slightly increased in untreated hypertensive patients. However, these findings provide no information on the intrinsic mechanical properties of the wall material. To address this question, we determined intima-media wall thickness, wall-to-lumen ratio, and incremental elastic modulus in the radial artery of 25 untreated hypertensive patients with blood pressure of 150 +/- 14/103 +/- 6 mm Hg (mean +/- SD) and 25 matched control subjects with blood pressure of 118 +/- 9/79 +/- 6 mm Hg. High-resolution echotracking for assessment of internal diameter and intima-media wall thickness was combined with measurements of blood flow velocity by Doppler and blood pressure by photoplethysmography. In addition, isobaric compliance and distensibility and incremental elastic modulus were measured at peak diameter during reactive hyperemia after a 5-minute brachial occlusion. No significant difference was found between the two groups for isobaric compliance or distensibility at baseline or during hyperemia. However, incremental elastic modulus at 100 mg Hg tended to be lower in hypertensive patients than control subjects (1.9 +/- 1.1 versus 2.5 +...Continue Reading

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Citations

Sep 12, 2000·Current Hypertension Reports·J B Park, E L Schiffrin
Aug 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H GardinerK Marsál
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May 11, 2006·Journal of Hypertension·Gianfranco Parati, Luciano Bernardi
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Jul 20, 2006·International Journal of Nursing Terminologies and Classifications : the Official Journal of NANDA International·Rita de Cassia Gengo de SilvaFernanda Marciano Consolim-Colombo
Feb 14, 2008·IEEE Transactions on Bio-medical Engineering·Alexander Roytvarf, Vladimir Shusterman
Jun 28, 2005·IEEE Transactions on Bio-medical Engineering·Meir NitzanAlan Murray
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May 29, 2010·American Journal of Hypertension·Jennifer N NjorogeKim Sutton-Tyrrell
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Jan 25, 2003·Journal of Hypertension·Michael BarenbrockMartin Hausberg
Nov 24, 1999·The American Journal of Physiology·G FauryW A Boyle

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