PMID: 8948448Jun 15, 1995Paper

Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times

The Biochemical Journal
M CascanteH Kacser

Abstract

Control analysis of transit time, defined as tau = delta/J, has previously been considered with the constraint of low enzyme concentrations compared with free pools of metabolites [Meléndez-Hevia, Torres, Sicilia and Kacser (1990) Biochem. J. 265, 195-202]. One of the conclusions was that the sum of the control coefficients of the transition time with respect to enzyme concentration was -1. Here we demonstrate that, if the enzyme-bound pools are taken into consideration (which would be important at high enzyme concentrations and high affinities), the sum lies between 0 and -1. The transition time between two steady states, which are frequent physiological events, is mainly governed by time constants involved in changing the enzyme concentrations. Some physiological and evolutionary aspects are discussed.

Citations

May 11, 2011·Insect Biochemistry and Molecular Biology·Marcela NouzovaFernando G Noriega
Feb 19, 2011·Mathematical Biosciences·Baldiri SalvadoRui Alves
Sep 16, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Delphine Scaion, Philippe Sébert
May 23, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Björn SchwanhäusserDorothea Busse
Nov 4, 2000·Nature Biotechnology·D A Fell, A Wagner
Jul 1, 1996·FEBS Letters·B N KholodenkoM Cascante
Mar 19, 2003·Proceedings. Biological Sciences·Andreas Wagner
Aug 28, 2001·Proceedings. Biological Sciences·A Wagner, D A Fell
Jan 1, 2014·International Scholarly Research Notices·Fernando G Noriega
Jun 5, 2003·Journal of Theoretical Biology·Qingwu YangJeffrey J Morgan

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