Control and function of the bloodstream variant surface glycoprotein expression sites in Trypanosoma brucei

International Journal for Parasitology
Luc VanhammeEtienne Pays

Abstract

African trypanosomes escape the host immune response through a periodical change of their surface coat made of one major type of protein, the variant surface glycoprotein. From a repertoire of a thousand variant surface glycoprotein genes available, only one is expressed at a time, and this takes place in a specialised expression site itself selected from a collection of an estimated 20-30 sites. As the specialised expression sites are long polycistronic transcription units, the variant surface glycoprotein is co-transcribed with several other genes termed expression site-associated genes. How do the trypanosomes only use a single specialised expression site at a time? Why are there two dozen specialised expression sites? What are the functions of the other genes of these transcription units? We review the currently available answers to these questions.

References

Apr 1, 1991·Molecular and Cellular Biology·I C FlorentH Eisen
May 1, 1991·Molecular and Cellular Biology·K GottesdienerL H Van der Ploeg
Dec 1, 1990·Molecular and Biochemical Parasitology·S AlexandreE Pays
Aug 1, 1990·Molecular and Biochemical Parasitology·M CrozatierP Borst
Jun 1, 1988·Molecular and Cellular Biology·S AlexandreE Pays
Jul 21, 1995·The Journal of Biological Chemistry·M A SanchezS M Landfear
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M ChaudhriP Overath
Apr 19, 1996·The Journal of Biological Chemistry·R W MorganJ E Donelson
May 1, 1996·Molecular and Biochemical Parasitology·S AlexandreE Pays
Jul 1, 1996·Molecular and Biochemical Parasitology·S LipsE Pays
Oct 18, 1996·Molecular and Biochemical Parasitology·V B CarruthersG A Cross
Mar 13, 1998·Molecular and Biochemical Parasitology·P Borst, F van Leeuwen
May 9, 1998·Molecular and Biochemical Parasitology·E Pays, D P Nolan
May 9, 1998·Molecular and Biochemical Parasitology·P BorstG Rudenko
May 9, 1998·Molecular and Biochemical Parasitology·G A CrossM Navarro
Aug 27, 1998·Molecular and Biochemical Parasitology·M Navarro, G A Cross

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Citations

Mar 24, 2004·Trends in Parasitology·Richard McCulloch
Jan 28, 2003·International Journal for Parasitology·J D BarryR McCulloch
Mar 19, 2002·Molecular and Biochemical Parasitology·Sebastian UlbertPiet Borst
Jul 11, 2002·Molecular and Biochemical Parasitology·Matthew BerrimanGloria Rudenko
May 14, 2003·Molecular and Biochemical Parasitology·Karen SheaderGloria Rudenko
Apr 24, 2002·Antioxidants & Redox Signaling·Daniel J Steenkamp
Dec 6, 2005·Nucleic Acids Research·Chris Proudfoot, Richard McCulloch
Sep 12, 2006·Nucleic Acids Research·Cathryn RehmeyerMark Farman
Nov 21, 2012·PLoS Neglected Tropical Diseases·Guy CaljonPatrick De Baetselier
Jun 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ali KassemLuc Vanhamme
Feb 15, 2011·Journal of Proteomics·Anne GeigerPhilippe Holzmuller
Aug 4, 2004·Current Opinion in Microbiology·Etienne PaysDavid Pérez-Morga
Nov 18, 2005·Molecular and Biochemical Parasitology·Chris Proudfoot, Richard McCulloch
Oct 5, 2019·Tropical Medicine and Infectious Disease·Christopher K KariukiStefan Magez
Aug 23, 2003·The Journal of Biological Chemistry·Joanna S Bell, Richard McCulloch
Jan 25, 2005·Molecular and Biochemical Parasitology·David WalgraffeLuc Vanhamme

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African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.