PMID: 9429097Jan 16, 1998Paper

Control and measurement of permeability for design of microcapsule cell delivery system

Journal of Biomedical Materials Research
M BrissováT G Wang

Abstract

Transplantation of immunoisolated islets of Langerhans has been proposed as a promising approach to treating insulin-dependent diabetes mellitus. Recently, a cell delivery system based on a multicomponent microcapsule has been designed for the immunoisolation of insulin-secreting pancreatic islets. The capsule, formed by polyelectrolyte complexation of sodium alginate and cellulose sulfate with poly(methylene-co-guanidine), markedly has improved mechanical strength compared with the widely used alginate/poly(L-lysine) capsules. It also provides a flexibility for readily adjusting membrane thickness and capsule size, and, more important, the membrane permeability can be altered over a wide range of molecular sizes. To rigorously test the capsule diffusion properties, we have improved capsule permeability measurement by using two complementary methods: (1) size exclusion chromatography with dextran standards; and (2) newly developed methodology for assessing permeability to a series of biologically relevant proteins. Viability and function of rat pancreatic islets enclosed in the capsules with different permeability were tested in vitro. The insulin secretion of encapsulated islets was well preserved even though slightly delayed ...Continue Reading

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Citations

Jan 16, 1998·Journal of Biomedical Materials Research·I LacíkT Wang
Dec 1, 2006·Journal of Materials Science. Materials in Medicine·S A AbbahK D K Luk
Jul 24, 2013·Advanced Drug Delivery Reviews·Anne Mari A RokstadBerit L Strand
Aug 7, 2013·Advanced Drug Delivery Reviews·David W Scharp, Piero Marchetti
Nov 26, 2013·Advanced Drug Delivery Reviews·Paul de VosMarijke M Faas
Aug 16, 2000·Advanced Drug Delivery Reviews·H UludagP A Tresco
Aug 16, 2000·Advanced Drug Delivery Reviews·B Ríhová
Mar 12, 2003·Advanced Drug Delivery Reviews·Sarah L Tao, Tejal A Desai
Feb 10, 1998·Artificial Organs·T G Wang
Jan 5, 2002·Diabetes Technology & Therapeutics·A Prokop
Jan 3, 2006·Diabetes Technology & Therapeutics·Seda KizilelEmmanuel Opara
Jul 21, 2012·Journal of Chromatographic Science·Qingqiang MengZhiguo Su
Nov 10, 2001·Annual Review of Biomedical Engineering·E L Chaikof
Aug 27, 2009·Biologics : Targets & Therapy·Satya Prakash, Aleksandra Malgorzata Urbanska
Feb 24, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Rishad R JivaniBhagyesh P Jhala
Mar 27, 2012·Current Opinion in Biotechnology·Curtis Woodford, Peter W Zandstra
May 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·E H NafeaP J Martens
Jun 25, 2009·Biotechnology Progress·Jean-Michel RabanelPatrice Hildgen
Feb 11, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Corinne A HoesliJames M Piret
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·Ying MaXiaojun Ma
Jul 28, 2011·Journal of Biomedical Materials Research. Part a·Kerim M Gattás-AsfuraCherie L Stabler
Sep 8, 2004·Advanced Drug Delivery Reviews·Tejal A DesaiArfaan Rampersaud
Mar 24, 2006·International Journal of Pharmaceutics·Pietro MatricardiFranco Alhaique
Aug 13, 2002·Expert Opinion on Biological Therapy·Tejal A Desai
Sep 1, 2010·Therapeutic Delivery·Gorka OriveJosé Luis Pedraz
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alexander Ulrich ErnstMinglin Ma
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingxian HuangJianhua Zhou
Apr 17, 2020·ACS Applied Polymer Materials·Vincenzo CalabreseKaren J Edler

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