Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy

Coordination Chemistry Reviews
Jessica D Knoll, Claudia Turro

Abstract

The use of visible light to produce highly selective and potent drugs through photodynamic therapy (PDT) holds much potential in the treatment of cancer. PDT agents can be designed to follow an O2-dependent mechanism by producing highly reactive species such as (1)O2 and/or an O2 independent mechanism through processes such as excited state electron transfer, covalent binding to DNA or photoinduced drug delivery. Ru(II)-polypyridyl and Rh2(II,II) complexes represent an important class of compounds that can be tailored to exhibit desired photophysical properties and photochemical reactivity by judicious selection of the ligand set. Complexes with relatively long-lived excited states and planar, intercalating ligands localize on the DNA strand and photocleave DNA through (1)O2 production or guanine oxidation by the excited state of the chromophore. Photoinduced ligand substitution occurs through the population of triplet metal centered ((3)MC) excited states and facilitates covalent binding of the metal complex to DNA in a mode similar to cisplatin. Ligand photodissociation also provides a route to selective drug delivery. The ability to construct metal complexes with desired light absorbing and excited state properties by ligand...Continue Reading

References

Feb 1, 2007·Chemical Society Reviews·Michael J Hannon
Oct 17, 2007·Chembiochem : a European Journal of Chemical Biology·Leonardo ZayatRoberto Etchenique
Jan 29, 2008·Recent Patents on Anti-cancer Drug Discovery·Irena Kostova
Oct 30, 2009·Chemical Communications : Chem Comm·Soledad Betanzos-LaraPeter J Sadler
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Katherine S Lovejoy, Stephen J Lippard
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicola J FarrerPeter J Sadler
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston

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Citations

Feb 11, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·William I O'MalleyBim Graham
Jan 12, 2016·The Journal of Physical Chemistry. a·Li-Li WangHai-Yang Liu
Oct 20, 2015·Accounts of Chemical Research·Thomas A Shell, David S Lawrence
Jul 21, 2015·Journal of Photochemistry and Photobiology. A, Chemistry·Lei ZhuRonald J Clark
Apr 14, 2016·Journal of the American Chemical Society·Adam N BoyntonJacqueline K Barton
Jul 18, 2015·Accounts of Chemical Research·Jessica D KnollClaudia Turro
Jul 15, 2015·Accounts of Chemical Research·Samya Banerjee, Akhil R Chakravarty
Jul 8, 2016·Journal of the American Chemical Society·Amir AliyanAngel A Martí
Jul 28, 2016·The Journal of Physical Chemistry. a·Christian ReichardtBenjamin Dietzek
Aug 23, 2016·ACS Applied Materials & Interfaces·Xiao LiFude Feng
May 2, 2017·ACS Chemical Neuroscience·Ricardo CabreraRoberto Etchenique
Nov 25, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Koushambi Mitra
Jan 4, 2017·Physical Chemistry Chemical Physics : PCCP·G CarroneR Etchenique
Dec 13, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhigang Zhang, Ruihui Dai
Jan 26, 2017·Chemical Communications : Chem Comm·Leli ZengHui Chao
Jan 14, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Natalia ZabarskaSven Rau
Apr 22, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·S L HopkinsSylvestre Bonnet
Jun 1, 2017·Chemistry : a European Journal·Wen SunSi Wu
Jul 21, 2017·Inorganic Chemistry·Felipe Diógenes AbreuIdalina Maria Moreira de Carvalho
Jul 6, 2017·The Journal of Physical Chemistry. a·Christian ReichardtBenjamin Dietzek
Sep 30, 2015·Scientific Reports·Lihua LuChung-Hang Leung
Nov 28, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Wen SunSi Wu
Oct 7, 2016·Chemical Communications : Chem Comm·Matthew B MinusZachary T Ball
Oct 18, 2016·Chemical Communications : Chem Comm·Zhijun ChenSi Wu
Sep 22, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Huaiyi HuangHui Chao
Oct 1, 2015·Chemical Communications : Chem Comm·B A AlbaniC Turro
Jan 9, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Dik-Lung MaChung-Hang Leung
Nov 9, 2017·Chemical Communications : Chem Comm·F BolzeV Heitz
Nov 28, 2017·Chemical Society Reviews·Fergus E PoyntonThorfinnur Gunnlaugsson
Sep 14, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Younes EllahiouiSantiago Gómez-Ruiz

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