Feb 1, 1986

Control by major histocompatibility complex genes of macrophage interaction with thymocytes during induction of T-effectors of graft vs host reaction. I. Genetic control on the cellular level

Genetika
V G GalaktionovP R Poznakhirev

Abstract

H-2 complex control of interaction between macrophages and thymocytes during induction of T-cell effectors GVH was studied. Intensity of the local GVH reaction was evaluated by the index of the lymph nodes enlargement. Genes of the H-2 system control interaction of macrophages with thymocytes during the formation of T-cell effectors GVH. H-2K subregion genes identity of interacting cells was necessary and sufficient for the effective induction of T-effectors GVH. I and D region differences did not affect the formation of T-cells inducing GVH.

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Mentioned in this Paper

T-Lymphocyte
Thymocyte
Graft Vs Host Reaction
Lymph Nodes
Major Histocompatibility Complex
Lymphocyte Cooperation
H-2 Antigens
Immune-Associated Antigens
Macrophage
Control Interaction

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