PMID: 36751Jan 1, 1979

Control factors of granulopoiesis in human serum

American Journal of Hematology
R W Bolin, W A Robinson

Abstract

The role of serum factors in the modulation of production of colony-stimulating activity (CSA) has been investigated. A factor has been described, and partially characterized, in human serum that has the capacity to stimulate increased synthesis and release of CSA by human mononuclear cells (MNC). MNC RNA and protein synthesis are required to demonstrate this effect of serum, but DNA synthesis and mitotic division are not required. The factor in serum resulting in this effect is a heat-labile protein with a molecular weight slightly greater than that of CSA.

References

Nov 24, 1977·The New England Journal of Medicine·W A RobinsonO G Stonington
Aug 1, 1977·Journal of Cellular Physiology·R W Bolin, W A Robinson
Sep 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·D W Golde, M J Cline
Mar 1, 1975·The Journal of Clinical Investigation·F W Ruscetti, P A Chervenick
Dec 30, 1972·Lancet·D W GoldeM J Cline
Apr 19, 1974·Nature·M J Cline, D W Golde
Feb 3, 1972·The New England Journal of Medicine·P QuesenberryM Smith
Nov 1, 1972·The Journal of Clinical Investigation·D W Golde, M J Cline
Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson

Related Concepts

Protein Inducer MGI
Alkaline DNase
Granulocyte
Hematopoiesis, Medullary
Hydrogen-Ion Concentration
Pronase
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Trypure

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