Feb 5, 1976

Control of 5-aminolaevulinate synthetase activity in Rhodopseudomonas spheroides

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
E A Wider de XifraA Neuberger

Abstract

Rhodopseudomonas spheroides can grow in a defined medium with either light or oxygen as an energy source. Cells grown anaerobically or at very low oxygen tensions are rich in the photosynthetic pigment bacteriochlorophyll, whereas this pigment is virtually absent in cells grown under high oxygen tensions. Aminolaevulinate synthetase, the first enzyme on the pathway to bacteriochlorophyll, appears to play an important role in the control of bacteriochlorophyll synthesis. Thus, the enzyme has a high activity in extracts of pigmented cells and a low activity in extracts of non-pigmented cells. Further, oxygenation of a pigmented culture causes immediate cessation of pigment synthesis and produces a rapid fall in the activity of aminolaevulinate synthetase. This loss of activity appears to be due to the loss of an endogenous activator of the enzyme. Thus, pigmented cells contain cystine trisulphide, which at muM concentrations is an activator of aminolaevulinate synthetase, while oxygenation causes a rapid fall in the cellular content of this trisulphide. Cystathionase (EC 4.2.1.15) extracted from pigmented cells can catalyse the formation of cystine trisulphide from cystine, while rhodanese (EC 2.8.1.1) extracted from the same cel...Continue Reading

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Mentioned in this Paper

Dioxygen
Alveolar Ventilation Function
Sulfurtransferase
Desmolases
Arsenic trisulfide
5-Aminolevulinate synthase
Pigment
Light
Thioethers
Rhodobacter sphaeroides

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