PMID: 3758074Sep 15, 1986Paper

Control of a futile urea cycle by arginine feedback inhibition of ornithine carbamoyltransferase in Agrobacterium tumefaciens and Rhizobia

European Journal of Biochemistry
S VissersJ M Wiame

Abstract

In Agrobacterium tumefaciens and Rhizobia arginine can be used as the sole nitrogenous nutrient via degradation by an inducible arginase. These microorganisms were found to exhibit arginine inhibition of ornithine carbamoyltransferase activity. This inhibition is competitive with respect to ornithine (Km for ornithine = 0.8 mM; Ki for arginine = 0.05 mM). This type of urea cycle regulation has not been observed among other microorganisms which degrade arginine via an arginase. The competitive pattern of this inhibition leads to its being inoperative in ornithine-grown cells, where the intracellular concentration of ornithine is high. In arginine-grown cells, however, the intracellular arginine and ornithine concentrations are compatible with inhibition and ornithine recycling appears to be effectively blocked in vivo.

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Citations

Jan 8, 1999·Plant Physiology·A Goldraij, J C Polacco
Mar 8, 2014·Critical Reviews in Microbiology·Michael Frederick Dunn
Jun 24, 2021·FEMS Microbiology Reviews·Victor M HernándezMichael F Dunn

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