PMID: 9557693Apr 29, 1998Paper

Control of adenovirus early gene expression during the late phase of infection

Journal of Virology
S P Fessler, C S Young

Abstract

The adenovirus gene regulatory program occurs in two distinct phases, as defined by the onset of DNA replication. During the early phase, the E1A, E1B, E2, E3, and E4 genes are maximally expressed, while the major late promoter (MLP) is minimally expressed and transcription is attenuated. After the onset of DNA replication, the IVa2 and pIX genes are expressed at high levels, transcription from the MLP is unattenuated and fully activated, and early gene expression is repressed. Although the cis elements and trans-acting factors responsible for the late-phase activation of the MLP have been identified and characterized and the role of DNA replication in activation has been established, the mechanism(s) underlying the commensurate decrease in early gene expression has yet to be elucidated. The results of this study demonstrate that this decrease depends on a fully functional MLP. Specifically, virus mutants with severely deficient transcription from the MLP exhibit a marked increase in expression of the E1A, E1B, and E2 early genes. These increases were observed at the level of transcription initiation, mRNA accumulation, and protein production. In addition, expression from the late gene pIX, which is not contained within the maj...Continue Reading

References

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Citations

Sep 17, 2020·Viruses·Jón Pol GalesMaria Dimitrova
Jul 10, 1999·Immunological Reviews·J A Mahr, L R Gooding
Oct 20, 2000·The Journal of General Virology·W C Russell
Jun 28, 2003·Journal of Virology·Kristina LöhrMatthias Dobbelstein
Apr 25, 2000·Molecular and Cellular Biology·B S Wolner, J D Gralla
Nov 2, 1999·Virology·S P Fessler, C S Young

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