Control of adipogenic commitment by a STAT3-VSTM2A axis.

American Journal of Physiology. Endocrinology and Metabolism
Manal Al DowMathieu Laplante

Abstract

White adipose tissue (WAT) is a dynamic organ that plays crucial roles in controlling metabolic homeostasis. During development and periods of energy excess, adipose progenitors are recruited and differentiate into adipocytes to promote lipid storage capability. The identity of adipose progenitors and the signals that promote their recruitment are still incompletely characterized. We have recently identified V-set and transmembrane domain-containing protein 2A (VSTM2A) as a novel protein enriched in preadipocytes that amplifies adipogenic commitment. Despite the emerging role of VSTM2A in promoting adipogenesis, the molecular mechanisms regulating Vstm2a expression in preadipocytes are still unknown. To define the molecular mechanisms controlling Vstm2a expression, we have treated preadipocytes with an array of compounds capable of modulating established regulators of adipogenesis. Here, we report that Vstm2a expression is positively regulated by PI3K/mTOR and cAMP-dependent signaling pathways and repressed by the MAPK pathway and the glucocorticoid receptor. By integrating the impact of all the molecules tested, we identified signal transducer and activator of transcription 3 (STAT3) as a novel downstream transcription factor ...Continue Reading

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Citations

May 1, 2021·Animals : an Open Access Journal From MDPI·Hongfang GuoLinsen Zan

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Datasets Mentioned

BETA
GSE27826
GSE56872

Methods Mentioned

BETA
PCR
transfection
fluorescence microscopy
Immunoprecipitation
ChIP-Seq

Software Mentioned

Trimmomatic
MUGQIC
MACS2
deepTools
BWA

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