Control of alginate synthesis in Pseudomonas aeruginosa: regulation of the algR1 gene

Biochemical and Biophysical Research Communications
K Kimbara, A M Chakrabarty

Abstract

The triggering of mucoidy (formation of the exopolysaccharide alginate) in Pseudomonas aeruginosa is accomplished primarily in Cystic Fibrosis lung environment through activation of the promoter of a gene algD, which encodes GDP-mannose dehydrogenase, by the product of a regulatory gene algR1. Both algD and algR1 promoter regions have significant homology, including the presence of sequences recognized by the RNA polymerase sigma 54. We demonstrate that the algR1 promoter is partly constitutive and its activation, similar to that of algD, is dependent on high osmolarity as well as the presence of its own gene product and is repressed by high concentrations of AlgR1. The RpoN sigma factor also plays a critical role in the transcription of both algD and algR1 genes.

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S InouyeT Nakazawa
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K S Ishimoto, S Lory
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R P Gunsalus, C Yanofsky

❮ Previous
Next ❯

Citations

Jul 1, 1993·World Journal of Microbiology & Biotechnology·J L Ramos, S Marqués
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J KatoA M Chakrabarty
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J Kato, A M Chakrabarty
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C B WhitchurchJ S Mattick
Feb 28, 2001·Microbes and Infection·N HøibyA Kharazmi
Jan 23, 2010·Microbiology·Jessica M HaginsLaura Silo-Suh
Jul 8, 2014·Frontiers in Cellular and Infection Microbiology·Yuta OkkotsuMichael J Schurr
May 3, 2000·Molecular Microbiology·J C BoucherV Deretic
Apr 13, 2019·International Journal of Molecular Sciences·Anjali Y BhagirathKangmin Duan
Dec 1, 1992·Journal of Bacteriology·N A ZielinskiA M Chakrabarty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.