PMID: 9545224May 9, 1998Paper

Control of alternative splicing of potassium channels by stress hormones

Science
J Xie, D P McCobb

Abstract

Many molecular mechanisms for neural adaptation to stress remain unknown. Expression of alternative splice variants of Slo, a gene encoding calcium- and voltage-activated potassium channels, was measured in rat adrenal chromaffin tissue from normal and hypophysectomized animals. Hypophysectomy triggered an abrupt decrease in the proportion of Slo transcripts containing a "STREX" exon. The decrease was prevented by adrenocorticotropic hormone injections. In Xenopus oocytes, STREX variants produced channels with functional properties associated with enhanced repetitive firing. Thus, the hormonal stress axis is likely to control the excitable properties of epinephrine-secreting cells by regulating alternative splicing of Slo messenger RNA.

References

Dec 1, 1989·Acta Physiologica Scandinavica·S CeccatelliT Hökfelt
Jan 1, 1996·Ion Channels·C J LingleJ P Ding
Sep 5, 1996·Brain Research. Molecular Brain Research·J E KrausJ O McNamara

❮ Previous
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Citations

Apr 11, 2006·The Journal of Membrane Biology·G GessnerS H Heinemann
Oct 13, 2010·Pflügers Archiv : European journal of physiology·Asser Nyander PoulsenDan Arne Klaerke
Mar 3, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sevgi GurkanLisa M Satlin
Mar 15, 2011·Journal of the Association for Research in Otolaryngology : JARO·Corey S FruchtDhasakumar S Navaratnam
Mar 5, 2003·Hormones and Behavior·David P McCobbGabriele Flügge
May 7, 2002·Journal of Neuroscience Methods·Sahar F MahmoudDavid P McCobb
Mar 27, 2001·Biochimica Et Biophysica Acta·B E ShmuklerS L Alper
Jul 28, 2001·Progress in Neurobiology·P J Grabowski, D L Black
May 17, 2002·Progress in Neurobiology·Pankaj Sah, E S Louise Faber
Jun 29, 2002·Molecular and Cellular Endocrinology·Amanda J HoldimanSarah K England
Sep 2, 2004·Nature Reviews. Molecular Cell Biology·Chanseok Shin, James L Manley
Nov 12, 2013·Nature Structural & Molecular Biology·Michael T LovciGene W Yeo
Feb 9, 2007·International Journal of Impotence Research·K P DaviesA Melman
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Victoria P Korovkina, Sarah K England
Jul 29, 2003·Aging Cell·Eran Meshorer, Hermona Soreq
Dec 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lijun TianMichael J Shipston
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thomas J BellJames H Eberwine
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Harpreet SinghLigia Toro
Jun 25, 2008·Molecular & Cellular Proteomics : MCP·Jiusheng YanJames S Trimmer
Mar 29, 2006·The Journal of General Physiology·Bin WangRobert Brenner
Jun 20, 2008·The Journal of General Physiology·Thirumalini VaithianathanAlejandro Dopico
Nov 28, 2013·The Journal of General Physiology·Chris ShelleyAndrea L Meredith
Dec 20, 2002·DNA and Cell Biology·Peter StoilovStefan Stamm
Aug 3, 2001·The EMBO Journal·S Weg-RemersH König
May 24, 2006·Genes, Brain, and Behavior·J Y YuN S Atkinson
Jul 22, 1999·Annals of the New York Academy of Sciences·B Rudy
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Jul 22, 1999·Annals of the New York Academy of Sciences·E M JonesR Fettiplace
Oct 17, 2003·The Journal of Physiology·Hélène A WidmerMichael J Shipston
Aug 13, 2008·Annual Review of Physiology·Anthony A Fodor, Richard W Aldrich
Apr 1, 1999·Annual Review of Physiology·R Fettiplace, P A Fuchs
Feb 24, 2004·Annual Review of Physiology·Xiang Dong TangToshinori Hoshi
Oct 16, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jin ZhangDan R Halm
Jun 27, 2008·American Journal of Physiology. Renal Physiology·Genevieve EstiloLisa M Satlin
Feb 7, 2009·Physiology·Shangwei HouToshinori Hoshi
Aug 26, 2010·Physiological Genomics·Steven A Fisher

❮ Previous
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