PMID: 9533954May 12, 1998Paper

Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development

Mechanisms of Development
M QiuJ L Rubenstein

Abstract

Here we report the isolation, sequence and developmental expression in the central nervous system of several members of the chicken and mouse Nkx gene family. These are among the earliest genes to be regionally expressed in the neural plate; they are expressed just above the axial mesendoderm (prechordal mesendoderm and notochord). Each Nkx gene has a distinct spatial pattern of expression along the anterior-posterior axis of the ventral central nervous system: Nkx-2. 2 is expressed along the entire axis, whereas Nkx-2.1 is restricted to the forebrain, and Nkx-6.1 and Nkx-6.2 are largely excluded from the forebrain. They are also expressed in distinct patterns along the dorsal-ventral axis. These genes are expressed in both the ventricular and mantle zones; in the mantle zone Nkx-6.1 is co-expressed with Islet-1 in a subset of motor neurons. Like other Nkx genes, expression of Nkx-6.1 is induced by the axial mesendoderm and by sonic hedgehog protein. BMP-7 represses Nkx-6.1 expression. While the notochord can induce Nkx-6.1 expression in the anterior neural plate, sonic hedgehog protein does not, suggesting that the notochord produces additional molecules that can regulate ventral patterning.

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Citations

Oct 12, 1999·The Journal of Comparative Neurology·D D EisenstatJ L Rubenstein
Jan 30, 2010·Development Genes and Evolution·Karl R WottonKatharine E Lewis
Mar 16, 2013·Brain Structure & Function·J A Moreno-BravoE Puelles
Aug 7, 1998·Biological Psychiatry·J L Rubenstein
Jun 25, 2003·Experimental Neurology·Hitoshi KawanoShioko Kimura
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Jan 30, 2002·Trends in Neurosciences·Elisa Martí, Paola Bovolenta
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Feb 19, 2000·Current Opinion in Neurobiology·R A Cornell, T V Ohlen
Nov 19, 2002·Genes & Development·Madelen PerssonJames Briscoe
Mar 3, 2005·Genes & Development·Despina StamatakiJames Briscoe
Jan 24, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rasmus KlinckMette C Jørgensen
Feb 6, 2013·PloS One·Jennifer A MaierBrian D Harfe
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lan-Hsiang WangMarshall Nirenberg
Feb 16, 2007·Gene Expression Patterns : GEP·Simon G SprecherVolker Hartenstein
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Jun 16, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan Antonio Moreno-BravoEduardo Puelles
Sep 6, 2012·The Journal of Comparative Neurology·Gilbert LauterGiselbert Hauptmann
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Apr 28, 2004·Developmental Biology·Leigh WilsonMalcolm Maden

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