Control of apoptosis by asymmetric cell division.

PLoS Biology
Julia Hatzold, B Conradt

Abstract

Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell division in the nematode Caenorhabditis elegans is mediated by a pathway involving three genes, dnj-11 MIDA1, ces-2 HLF, and ces-1 Snail, that directly control the enzymatic machinery responsible for apoptosis. Interestingly, the MIDA1-like protein GlsA of the alga Volvox carteri, as well as the Snail-related proteins Snail, Escargot, and Worniu of Drosophila melanogaster, have previously been implicated in asymmetric cell division. Therefore, C. elegans dnj-11 MIDA1, ces-2 HLF, and ces-1 Snail may be components of a pathway involved in asymmetric cell division that is conserved throughout the plant and animal kingdoms. Furthermore, based on our results, we propose that this pathway directly controls the apoptotic fate in C. elegans, and possibly other animals as well.

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Citations

Nov 6, 2009·Annual Review of Genetics·Barbara Conradt
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Amy J PrunuskeElizabeth Anne Craig
Dec 15, 2010·Nature Reviews. Cancer·Malia B Potts, Scott Cameron
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Oct 5, 2010·Cell Stem Cell·Amanda SierraMirjana Maletic-Savatic
Oct 19, 2016·Cell Cycle·Aysegül Kaymak, Holger Richly
Feb 9, 2017·Genes & Development·Ryan SherrardBarbara Conradt
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Aug 16, 2016·Genetics·Barbara ConradtDing Xue
Aug 18, 2021·Annals of the New York Academy of Sciences·Ehsan RazmaraSadegh Babashah
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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

AutoDeblur Gold WF AutoVisualize
Metamorph
BLAST

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