Control of blood flow in the cat spinal cord

Journal of Neurosurgery
O U Scremin, E E Decima

Abstract

Spinal cord blood flow (SCBF) and the effect of end-tidal CO2 concentration (ETCO2) on SCBF (CO2 reactivity) were studied in the lumbar spinal cord of cats by means of the hydrogen-clearance technique Hydrogen gas was administered by inhalation, and its level in spinal cord tissue was estimated amperometrically with small (75 micrometers) platinum electrodes. The average SCBF's at normocapnia (ETCO2 = 4%) of the ventral horn gray matter and of the white matter at several locations were 43.2 and 16.2 ml . 100 gm-1 . min-1, respectively. For gray and white matter, the values of CO2 reactivity, estimated by the coefficient of the regression of SCBF (ml . 100 gm-1 . min-1) on ETCO2 (ml . 100 ml-1) were 11.6 and 2.1, respectively. No differences in SCBF or CO2 reactivity were observed between intact animals kept under N2O-O2 ventilation and decerebrated animals with no anesthesia. After an acute spinal section, ventral horn SCBF and CO2 reactivity (measured eight segments below the cordotomy) were not altered, in spite of the profound neural depression present (that is, spinal shock). Orthodromic (dorsal root) stimulation of the ventral horn neurons induced an average increase in blood flow of 128% above control values. Antidromic (...Continue Reading

References

Jul 1, 1978·Physiological Reviews·W Kuschinsky, M Wahl
Dec 17, 1976·Brain Research·A N Sandler, C H Tator
Jul 1, 1977·Circulation Research·M L MarcusF M Abboud
Feb 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·I R Griffiths
Jan 1, 1971·Brain : a Journal of Neurology·J Olesen
Mar 1, 1980·Journal of Neurosurgery·D C LohseR Wohns
Nov 1, 1952·The Journal of Physiology·F A HOLTON, P HOLTON
Dec 29, 1953·The Journal of Physiology·L G BROCKJ C ECCLES
Jan 1, 1964·The American Journal of Physiology·M REIVICH
Feb 1, 1964·Circulation Research·K AUKLANDR W BERLINER
Jun 1, 1951·The Journal of Physiology·E J FIELDA F ROGERS
Jan 1, 1890·The Journal of Physiology·C S Roy, C S Sherrington

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Citations

Aug 21, 2013·The Spine Journal : Official Journal of the North American Spine Society·Amir Reza AmiriAdrian T H Casey
Jun 18, 1998·Archives of Physical Medicine and Rehabilitation·O U ScreminM A Mandelkern
Jun 25, 2005·Anesthesia and Analgesia·Tomoki Nishiyama

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