Control of blood pressure and risk of mortality in a cohort of older adults: the Berlin Initiative Study.

European Heart Journal
Antonios DourosElke Schaeffner

Abstract

To assess whether blood pressure (BP) values below 140/90 mmHg during antihypertensive treatment are associated with a decreased risk of all-cause mortality in community-dwelling older adults. Within the Berlin Initiative Study, we assembled a cohort of patients ≥70 years treated with antihypertensive drugs at baseline (November 2009-June 2011). End of prospective follow-up was December 2016. Cox proportional hazards models yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause mortality associated with normalized BP [systolic BP (SBP) <140 mmHg and diastolic BP (DBP) <90 mmHg] compared with non-normalized BP (SBP ≥140 mmHg or DBP ≥90 mmHg) overall and after stratification by age or previous cardiovascular events. Among 1628 patients (mean age 81 years) on antihypertensive drugs, 636 exhibited normalized BP. During 8853 person-years of follow-up, 469 patients died. Compared with non-normalized BP, normalized BP was associated with an increased risk of all-cause mortality (incidence rates: 60.3 vs. 48.5 per 1000/year; HR 1.26; 95% CI 1.04-1.54). Increased risks were observed in patients ≥80 years (102.2 vs. 77.5 per 1000/year; HR 1.40; 95% CI 1.12-1.74) and with previous cardiovascular events (98.3 ...Continue Reading

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Citations

Apr 22, 2019·European Heart Journal·Sebastian EwenMichael Böhm
Apr 23, 2020·The Journal of International Medical Research·Yuling YuYingqing Feng
Jun 7, 2019·Postgraduate Medical Journal·Junwen WangXiaogang Li
Nov 7, 2019·MMW Fortschritte der Medizin·Markus van der Giet
Oct 11, 2020·Age and Ageing·Francesco Mattace-Raso, Chakravarthi Rajkumar
Jan 14, 2021·Journal of Human Hypertension·Hussam Al GhoraniFelix Mahfoud
Jul 1, 2019·European Heart Journal·Thomas F Lüscher
Oct 16, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Taku InoueHisatomi Arima
Dec 18, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuharu Tabara

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