Control of Blood Vessel Formation by Notch Signaling

Advances in Experimental Medicine and Biology
Fabian Tetzlaff, Andreas Fischer

Abstract

Blood vessels span throughout the body to nourish tissue cells and to provide gateways for immune surveillance. Endothelial cells that line capillaries have the remarkable capacity to be quiescent for years but to switch rapidly into the activated state once new blood vessels need to be formed. In addition, endothelial cells generate niches for progenitor and tumor cells and provide organ-specific paracrine (angiocrine) factors that control organ development and regeneration, maintenance of homeostasis and tumor progression. Recent data indicate a pivotal role for blood vessels in responding to metabolic changes and that endothelial cell metabolism is a novel regulator of angiogenesis. The Notch pathway is the central signaling mode that cooperates with VEGF, WNT, BMP, TGF-β, angiopoietin signaling and cell metabolism to orchestrate angiogenesis, tip/stalk cell selection and arteriovenous specification. Here, we summarize the current knowledge and implications regarding the complex roles of Notch signaling during physiological and tumor angiogenesis, the dynamic nature of tip/stalk cell selection in the nascent vessel sprout and arteriovenous differentiation. Furthermore, we shed light on recent work on endothelial cell metabol...Continue Reading

Citations

Nov 9, 2019·Archives of Pharmacal Research·Juan ZhangZhiyi Zhang
Feb 1, 2019·Terapevticheskiĭ arkhiv·K V DergilevЕ V Parfyonova
Mar 19, 2020·EMBO Molecular Medicine·Sana S HasanAndreas Fischer
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Nan Ma, Jun Zhou
Jan 11, 2020·Journal of Nanobiotechnology·Wenjing LiuLongquan Shao
Sep 24, 2020·International Journal of Molecular Sciences·Ingrid Lilienthal, Nikolas Herold
Jan 12, 2021·Frontiers in Physiology·Jose Ricardo VieiraCarmen Ruiz de Almodovar
Jan 1, 2021·Frontiers in Cardiovascular Medicine·Alkmini A Papadopoulou, Regina Fluhrer
Oct 27, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laura Andrés-DelgadoNadia Mercader
Feb 5, 2021·Artificial Organs·Junichi SaitoYoshihiro Ishikawa
Apr 23, 2021·Tissue Engineering and Regenerative Medicine·Thi-Tuong Van NguyenPhuc Van Pham
May 11, 2021·Frontiers in Cell and Developmental Biology·Xiangfu MengDonghui Zhang

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