Control of bone resorption in mice by Schnurri-3.

Proceedings of the National Academy of Sciences of the United States of America
Marc N WeinLaurie H Glimcher

Abstract

Mice lacking the large zinc finger protein Schnurri-3 (Shn3) display increased bone mass, in part, attributable to augmented osteoblastic bone formation. Here, we show that in addition to regulating bone formation, Shn3 indirectly controls bone resorption by osteoclasts in vivo. Although Shn3 plays no cell-intrinsic role in osteoclasts, Shn3-deficient animals show decreased serum markers of bone turnover. Mesenchymal cells lacking Shn3 are defective in promoting osteoclastogenesis in response to selective stimuli, likely attributable to reduced expression of the key osteoclastogenic factor receptor activator of nuclear factor-κB ligand. The bone phenotype of Shn3-deficient mice becomes more pronounced with age, and mice lacking Shn3 are completely resistant to disuse osteopenia, a process that requires functional osteoclasts. Finally, selective deletion of Shn3 in the mesenchymal lineage recapitulates the high bone mass phenotype of global Shn3 KO mice, including reduced osteoclastic bone catabolism in vivo, indicating that Shn3 expression in mesenchymal cells directly controls osteoblastic bone formation and indirectly regulates osteoclastic bone resorption.

References

Nov 1, 1988·Endocrinology·N TakahashiT Suda
Feb 10, 1995·Cell·A ErlebacherR Derynck
Aug 2, 2001·The Journal of Endocrinology·G P ThomasE M Gardiner
Jul 12, 2002·Genesis : the Journal of Genetics and Development·Malcolm LoganClifford J Tabin
Jan 7, 2004·The Journal of Experimental Medicine·Mohamed OukkaLaurie H Glimcher
Apr 7, 2004·The Journal of Clinical Investigation·Toru AkuneHiroshi Kawaguchi
Feb 23, 2005·Nature·Florent ElefteriouGerard Karsenty
Sep 28, 2005·Bone·Sarah E WarnerTed S Gross
Dec 17, 2005·Trends in Molecular Medicine·Teiji WadaJosef M Penninger
May 9, 2006·The Journal of Clinical Investigation·Kazuhiro AokiRoland Baron
May 27, 2006·Science·Dallas C JonesLaurie H Glimcher
Nov 8, 2006·The Journal of Experimental Medicine·Kojiro SatoHiroshi Takayanagi
Nov 14, 2006·The Journal of Clinical Investigation·Ritsuko MasuyamaGeert Carmeliet
Aug 22, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christina N BennettOrmond A MacDougald
Oct 31, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michihiko UsuiBrendan F Boyce
Nov 16, 2007·The New England Journal of Medicine·Kenneth G SaagRobert Marcus
Feb 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaodong LiChris Paszty
Apr 15, 2008·Archives of Biochemistry and Biophysics·Koichi Matsuo, Naoko Irie
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jacques P BrownHenry G Bone
Oct 11, 2008·The Journal of Clinical Investigation·Antonios O AliprantisLaurie H Glimcher
Feb 5, 2009·Critical Reviews in Eukaryotic Gene Expression·T MartinNatalie A Sims
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chuwen LinLin He
Sep 1, 2009·Bone·Charles A O'Brien
Sep 13, 2011·Nature Medicine·Jinhu XiongCharles A O'Brien
Sep 13, 2011·Nature Medicine·Tomoki NakashimaHiroshi Takayanagi
Nov 30, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonios O AliprantisTed S Gross

❮ Previous
Next ❯

Citations

Aug 16, 2013·The Journal of Clinical Investigation·Jae-Hyuck ShimDallas C Jones
Apr 5, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lei ShuLianping Xing
Mar 10, 2018·International Journal of Molecular Sciences·Wesley O TuckerJulian A Tanner
Mar 23, 2018·Genes & Development·Masanari SeikeTakashi Nagasawa
Nov 2, 2017·Calcified Tissue International·Margot Van MechelenRik Lories
Sep 26, 2019·Nature Reviews. Rheumatology·Joachim SieperPierre Miossec
Jun 20, 2019·Biochemistry. Biokhimii︠a︡·O S KostarevaS V Tishchenko
Nov 27, 2019·JBMR Plus·Jochen G HofstaetterPaul Roschger
May 23, 2018·Nature Medicine·Ren XuMatthew B Greenblatt
Jul 6, 2019·Nature Communications·Yeon-Suk YangJae-Hyuck Shim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.