PMID: 2493534Jan 1, 1989Paper

Control of breathing in patients with short-term primary hypothyroidism

Lung
M GoriniG Scano

Abstract

In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (delta EMGd/delta Pet CO2 and delta VE/delta PetCO2), but significantly less delta P0.1/delta PetCO2 (p less than 0.05) and delta(Vt/Ti)/delta PetCO2 (p less than 0.05) response slopes. During replacement therapy with L-triiodothyronine (L-T3), Pimax (p less than 0.05), delta P0.1/delta PetCO2, and delta(Vt/Ti)/delta PetCO2 response slopes were found to be significantly increased (p less than 0.05 for both) while neither EMGd nor VE response changed significantly. We concluded that short-term hypothyroidism does not seem to be associated with blunted neural inspiratory output (EMGd), the respiratory control system seems to be affected mostly at a peripheral (m...Continue Reading

References

Nov 3, 1977·Nature·D IanuzzoC Williams
Jan 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D GrossP T Macklem
Jul 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J AskanaziJ M Kinney
Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M LopataR V Lourenço
Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F L Eldridge, K Z Vaughn
May 1, 1976·Journal of Applied Physiology·J P DerenneJ Milic-Emili
Mar 27, 1975·The New England Journal of Medicine·C W ZwillichJ V Weil
Mar 1, 1975·Respiration Physiology·W A WhitelawJ Milic-Emili
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·G ScanoR Sergysels
Dec 1, 1985·Journal of Endocrinological Investigation·N AmbrosinoA Pinchera
Aug 1, 1985·Journal of Applied Physiology·S N HussainJ A Dempsey
Aug 1, 1985·Respiration Physiology·G C SieckM J Belman
Sep 1, 1969·Journal of the Neurological Sciences·J Pearce, H Aziz
Jan 1, 1980·Annals of the New York Academy of Sciences·G B RossiE Affabris
Feb 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M LopataA S Ginzburg
Oct 1, 1984·Annals of Internal Medicine·K R RajagopalC W Zwillich
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A E GrassinoW Whitelaw
Apr 1, 1983·The American Review of Respiratory Disease·R P MillmanA I Pack
Sep 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R B BanzettJ Mead
Jul 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K M BaldwinL F Schrader
Nov 1, 1980·Chest·P T Macklem
Jan 1, 1958·A.M.A. Archives of Internal Medicine·S S WALDSTEINY T OESTER
Jan 1, 1960·The Journal of Clinical Investigation·W R WILSON, G N BEDELL
Jun 1, 1964·The American Journal of Medicine·R A MASSUMI, J L WINNACKER
Oct 1, 1951·The Journal of Clinical Endocrinology and Metabolism·E H LAMBERTL O MEDEROS

❮ Previous
Next ❯

Citations

Jan 10, 2001·The American Journal of the Medical Sciences·M BehniaM O Farber
Jul 3, 2013·American Journal of Surgery·Gang HanJieshou Li
Jul 1, 1993·The American Journal of Medicine·R DurantiG Scano
Nov 2, 2016·Thyroid : Official Journal of the American Thyroid Association·Jesper Roed SorensenLaszlo Hegedüs
Dec 3, 2013·Advances in Physiology Education·N J DomnikJ T Fisher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.