Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Rasmus RiviniusAndreas O Doesch

Abstract

Patients after heart transplantation (HTX) present with sinus tachycardia due to graft denervation. As elevated heart rates negatively affect survival, the aim of this study was to analyze the effects of ivabradine vs metoprolol succinate on heart rate, left ventricular (LV) mass and survival following HTX. This observational retrospective single-center study assessed 84 patients continuously receiving either ivabradine (n = 40) or metoprolol succinate (n = 44) within 2 years after HTX. Patients with dual therapy (ivabradine and metoprolol succinate), other beta blockers, amiodarone, or digitalis were excluded. Patient characteristics, post-transplant medication, heart rates, LV mass, and survival were investigated. Analysis of patient characteristics, immunosuppressive drug regimen, and post-transplant medication showed no significant differences between groups except for ivabradine and metoprolol succinate. Baseline heart rates differed not significantly between patients treated with ivabradine [87.0 beats per minute (bpm)] and metoprolol succinate (86.2 bpm; P = 0.6395). At 2-year follow-up, patients with ivabradine (76.7 bpm) had a significantly lower heart rate compared to baseline (P < 0.0001) and to metoprolol succinate ...Continue Reading

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Citations

Aug 11, 2020·Cardiology Research and Practice·Grzegorz M KubiakMichał O Zembala
Apr 7, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas MünzelPhilipp S Wild
Aug 11, 2019·Current Topics in Medicinal Chemistry·Yue ZhouKun Sun
Jun 24, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Rasmus RiviniusPhilipp Ehlermann
Nov 18, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Albert J OmlorUNKNOWN German COSYCONET Cohort
Aug 13, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Rasmus RiviniusPhilip W Raake

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