Control of cardiovascular risk factors in the Veterans Affairs Diabetes Trial in advanced type 2 diabetes.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
William C DuckworthVADT Investigators

Abstract

To present a status report on the Veterans Affairs Diabetes Trial (VADT), a multisite long-term study examining the effect of glucose control on cardiovascular (CV) complications in older patients with established, poorly controlled type 2 diabetes. We review the rationale, objectives, and design of the VADT and summarize the baseline data and the results achieved thus far. The main objective of this 20-site, 1,792-patient study is to ascertain whether intensive glucose control can reduce major CV events in patients with difficult-to-control type 2 diabetes. The study design consists of a standard treatment arm and an intensive treatment arm, with a goal of 1.5% difference in hemoglobin A1c values between the two groups. The trial is now in its fifth year, with completion expected in December 2007. The planned glucose separation has been achieved and maintained to this point. Blood pressure and hemoglobin A1c levels have been reduced from baseline values, and established CV risk factors are within recommended ranges. The current results of the VADT show that excellent control of glucose and CV risk factors can be achieved and maintained in the population studied. The results of these interventions on CV outcomes will ultimately...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 12, 1998·Annals of Internal Medicine·S VijanR A Hayward
May 12, 2001·Diabetes Care·W C DuckworthUNKNOWN VA Diabetes Trial
Oct 30, 2003·Journal of Diabetes and Its Complications·Carlos AbrairaUNKNOWN VA Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2

❮ Previous
Next ❯

Citations

Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
Mar 25, 2008·Clinical Cornerstone·Derek LeRoith
Sep 9, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·David R Matthews, Apostolos Tsapas
Jun 9, 2017·The Cochrane Database of Systematic Reviews·Marinella RuospoGiovanni Fm Strippoli
Nov 11, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Helena W RodbardJeffrey I Mechanick

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.