Control of cardiovascular variability during undisturbed wake-sleep behavior in hypocretin-deficient mice

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Alessandro SilvaniGiovanna Zoccoli

Abstract

The central neural mechanisms underlying differences in cardiovascular variability between wakefulness, non-rapid-eye-movement sleep (NREMS), and rapid-eye-movement sleep (REMS) remain poorly understood. These mechanisms may involve hypocretin (HCRT)/orexin signaling. HCRT signaling is linked to wake-sleep states, involved in central autonomic control, and impaired in narcoleptic patients. Thus, we investigated whether HCRT signaling plays a role in controlling cardiovascular variability during spontaneous behavior in HCRT-deficient mice. HCRT-ataxin3 transgenic mice lacking HCRT neurons (TG), knockout mice lacking HCRT peptides (KO), and wild-type controls (WT) were instrumented with electrodes for sleep recordings and a telemetric blood pressure transducer. Fluctuations of systolic blood pressure (SBP) and heart period (HP) during undisturbed wake-sleep behavior were analyzed with the sequence technique, cross-correlation functions, and coherent averaging of SBP surges. During NREMS, all mice had lower SBP variability, greater baroreflex contribution to HP control at low frequencies, and greater amplitude of the central autonomic and baroreflex changes in HP associated with SBP surges than during wakefulness. During REMS, all...Continue Reading

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Citations

Jan 19, 2016·Physiology & Behavior·Robert Lewis, J Thomas Curtis
Dec 12, 2012·Journal of Sleep Research·Alessandro SilvaniPietro Cortelli
Mar 1, 2014·Sleep Science·Pablo Torterolo, Michael H Chase
Sep 17, 2013·Journal of Sleep Research·Alessandro SilvaniGiovanna Zoccoli
May 23, 2015·Behavioural Brain Research·Pablo TorteroloEduardo R Migliaro
May 16, 2017·Photodiagnosis and Photodynamic Therapy·Emiyu OgawaTsunenori Arai
Oct 12, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Chiara Berteotti, Alessandro Silvani
May 4, 2013·Journal of Applied Physiology·Michael H Chase
Oct 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Alessandro Silvani, Roger A L Dampney
Dec 22, 2017·The Journal of Physiology·Viviana Lo MartireGiovanna Zoccoli

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