Control of Cell Attachment and Spreading on Poly(acrylamide) Brushes with Varied Grafting Density.

Langmuir : the ACS Journal of Surfaces and Colloids
Inga Lilge, Holger Schönherr

Abstract

To achieve spatial control of fibroblast cell attachment and spreading on a biocompatible polymer coating, the effect of poly(acrylamide) (PAAm) brushes with varied grafting density was investigated. The synthesis of the brushes was performed by surface-initiated atom transfer radical polymerization (SI-ATRP). Gold substrates were modified with binary self-assembled monolayers (SAMs) of an initiator and 16-mercaptohexadecanoic acid (MHDA) as an "inert" thiol to initiate the ATRP of AAm. By using different mixtures for the binary SAMs, a series of polymer brushes with varied grafting densities were prepared. The fractional coverage of surface bound initiator was determined by grazing incidence Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectrometry (ToF-SIMS), and contact angle measurements. A linear relationship between the Br/S ratio determined by XPS and ToF-SIMS versus the fraction of initiator on the surface determined by water contact angle measurements was observed. The varied initiation concentration on the gold substrates yielded PAAm brushes with different thicknesses, indicating a transition from mushroom to brush regimes with increasing gr...Continue Reading

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Citations

Jun 9, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Daniil E LarinValentina V Vasilevskaya
Feb 1, 2019·Advanced Materials·Liang YanYuliang Zhao
Feb 22, 2017·Soft Matter·Omed Al-JafGraham J Leggett
Jun 28, 2018·Journal of Materials Science. Materials in Medicine·Chrystalleni HadjicharalambousMaria Vamvakaki
Dec 28, 2017·Macromolecular Bioscience·Sabine GroßhansHolger Schönherr
Feb 21, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tony YuMichele Marcolongo
Aug 2, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Daniil E Larin, Elena N Govorun

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