Control of cell division and cell differentiation by deoxynucleotides in the early embryo of Xenopus laevis

Cell Differentiation
U LandströmS Løvtrup

Abstract

It is proposed that the deoxyriboside triphosphates present in the egg of Xenopus laevis support the synchronous cell divisions occurring during the earliest phase of embryonic development and that, as long as synchrony prevails, the cells are prevented from undergoing differentiation. This hypothesis has been tested by injecting deoxyribonucleotides into fertilized eggs. The following effects were observed: 1) the duration of synchrony is prolonged, 2) the morphological development is suppressed, an effect which is greatest when four nucleotides are injected together and 3) the synthesis of all kinds of RNA is inhibited, including the mRNA required for differentiation to occur.

References

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Citations

Jul 1, 1992·Developmental Biology·M Azzaria, J D McGhee
Jun 1, 1978·Cell Differentiation·H Løvtrup-ReinS Løvtrup
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H HartmanJ C Gerhart
Feb 25, 2011·PloS One·Livia VastagMarc W Kirschner
Jan 1, 1982·Differentiation; Research in Biological Diversity·N Satoh
Jan 1, 1986·Teratogenesis, Carcinogenesis, and Mutagenesis·N Zagris
Sep 1, 1978·Wilhelm Roux's Archives of Developmental Biology·Ulf Landström, Søren Løvtrup
Sep 24, 2019·Cell Cycle·Boyang Liu, Jörg Großhans
Dec 1, 1979·Wilhelm Roux's Archives of Developmental Biology·Jeremy OsbornMartin Stanisstreet

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