Control of cell fraction and population recovery during tissue regeneration in stem cell lineages

Journal of Theoretical Biology
Marissa RenardyChing-Shan Chou

Abstract

Multicellular tissues are continually turning over, and homeostasis is maintained through regulated proliferation and differentiation of stem cells and progenitors. Following tissue injury, a dramatic increase in cell proliferation is commonly observed, resulting in rapid restoration of tissue size. This regulation is thought to occur via multiple feedback loops acting on cell self-renewal or differentiation. Models of ordinary differential equations have been widely used to study the cell lineage system. Prior modeling studies have suggested that loss of homeostasis and initiation of tumorigenesis can be contributed to the loss of control of these processes, and the rate of symmetric versus asymmetric division of the stem cells may also be altered. While most of the previous works focused on analysis of stability, existence and uniqueness of steady states of multistage cell lineage models, in this work we attempt to understand the cell lineage model from a different perspective. We compare three variants of hierarchical stem cell lineage tissue models with different combinations of negative feedbacks and use sensitivity analysis to examine the possible strategies for the cells to achieve certain performance objectives. Our res...Continue Reading

Citations

Apr 10, 2020·Royal Society Open Science·Yanli WangChing-Shin Chou
Mar 3, 2020·RNA Biology·Lihong PengLiqian Zhou
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Jonathan DawsonRevathi Appali
Dec 10, 2020·Journal of Clinical Medicine·Arkadz KirshteinLeili Shahriyari

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