PMID: 42209Oct 1, 1979

Control of CFUc proliferation by selective endogenous inhibitors

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
A Balázs, K Barabás


The susceptibility of mouse bone marrow colony forming cells (CFUc) to three different types of proliferation inhibitors in capillary semisolid agar gel was studied. GI-3, a target specific peptide containing granulocyte fraction, T4-1, an oligospecific thymic factor of proteid nature, and the alkylating cytostatics dianhydrogalactitol (DAD) inhibit myeloid colony formation as a function of concentration. The respective MED values amount to 8, 10, and 0.002 microgram/ml. When compared with this same parameter 3H-TdR incorporation into DNA of liquid bone marrow cultures showed a single fold charge for the endogenous inhibitors (GI-3, T4-1) for the cytostatic (DAD) a 3 to 4 fold lower difference. It was demonstrated, that in competitive antagonism of GI-3 and colony stimulating factor the inhibitor prevails over CSF.


Jul 14, 1978·Blut·W R Paukovits, W Hinterberger
Jul 1, 1978·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R Maschler, H R Maurer
Jan 1, 1978·Cell and Tissue Kinetics·G Wagemaker, M F Peters
May 1, 1977·Mechanisms of Ageing and Development·A BalázsD Gaál
Mar 1, 1978·Journal of the National Cancer Institute·H E BroxmeyerA S Moore
Mar 1, 1978·Journal of the National Cancer Institute·H E BroxmeyerM A Moore
Oct 1, 1975·Journal of Cellular Physiology·F L BakerP R Galbraith
Nov 1, 1975·Cell and Tissue Kinetics·T J MacVittie, K F McCarthy
Jan 1, 1974·Analytical Biochemistry·S C ChouK A Conklin
Aug 1, 1974·Experimental Cell Research·M Granström
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E FibachL Sachs
Jul 1, 1973·Cell and Tissue Kinetics·N G Testa, B I Lord
Aug 1, 1971·The Australian Journal of Experimental Biology and Medical Science·D Metcalf
Jan 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M ParanL Sachs
Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson


Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Blazsek, G Mathé
Jan 1, 1991·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I BlazsekJ L Misset
Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Blazsek

Related Concepts

Cell Division Phases
Protein Inducer MGI
Colony-Forming Units, Hematopoietic
Thymus Gland

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