PMID: 42209Oct 1, 1979

Control of CFUc proliferation by selective endogenous inhibitors

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
A Balázs, K Barabás

Abstract

The susceptibility of mouse bone marrow colony forming cells (CFUc) to three different types of proliferation inhibitors in capillary semisolid agar gel was studied. GI-3, a target specific peptide containing granulocyte fraction, T4-1, an oligospecific thymic factor of proteid nature, and the alkylating cytostatics dianhydrogalactitol (DAD) inhibit myeloid colony formation as a function of concentration. The respective MED values amount to 8, 10, and 0.002 microgram/ml. When compared with this same parameter 3H-TdR incorporation into DNA of liquid bone marrow cultures showed a single fold charge for the endogenous inhibitors (GI-3, T4-1) for the cytostatic (DAD) a 3 to 4 fold lower difference. It was demonstrated, that in competitive antagonism of GI-3 and colony stimulating factor the inhibitor prevails over CSF.

References

Jul 14, 1978·Blut·W R Paukovits, W Hinterberger
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Jan 1, 1978·Cell and Tissue Kinetics·G Wagemaker, M F Peters
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Mar 1, 1978·Journal of the National Cancer Institute·H E BroxmeyerA S Moore
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Oct 1, 1975·Journal of Cellular Physiology·F L BakerP R Galbraith
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Citations

Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Blazsek, G Mathé
Jan 1, 1991·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I BlazsekJ L Misset
Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Blazsek

Related Concepts

Cell Division Phases
Protein Inducer MGI
NSC-132313
Colony-Forming Units, Hematopoietic
Polypeptides
Thymus Gland

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