Control of chemical pattern formation by a clock-and-wavefront type mechanism

Biophysical Chemistry
M KaernM Menzinger

Abstract

The segmentation of many animals ranging from insects to mammals involves the sequential formation of stationary stripes of gene expression that are perpendicular to the growth axis of the developing embryo. This process has been accounted for by a variety of theoretical "clock-and-wavefront" type models that involve the arrest of an oscillation (the clock) at a moving boundary (the wavefront). Here, we demonstrate experimentally that progressive arrest of a homogeneous oscillation can control the symmetry as well as the wavelength of spatial structures in a chemical system. We show how a spontaneously formed, labyrinthine pattern can be converted into a pattern composed of ordered, parallel stripes and confirm a previously predicted proportionality between the wavelength and the period of the homogeneous oscillation. Our experiments provide the first experimental demonstration of a general mechanism for the control of pattern formation that has been hypothesized to operate in the context of biological morphogenesis.

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Citations

Jun 7, 2013·Interdisciplinary Sciences, Computational Life Sciences·David G Míguez
Apr 17, 2014·Theory in Biosciences = Theorie in Den Biowissenschaften·Joseph E Hannon Bozorgmehr
Jul 18, 2006·Biophysical Chemistry·David G Míguez, Alberto P Muñuzuri
Jan 30, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Bryan C ThorneShayn M Peirce
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David G MíguezAlberto P Muñuzuri
Oct 4, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Patrick N McGraw, Michael Menzinger
Feb 21, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David G MíguezAlberto P Muñuzuri
Apr 12, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David G MíguezAlberto P Muñuzuri
Feb 21, 2006·Physical Review Letters·David G MíguezLorenz Kramer
Sep 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G DumazerA Lemarchand
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Patrick N McGraw, Michael Menzinger
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Patrick N McGrawAlberto P Muñuzuri
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Shrabani SenDeb Shankar Ray
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David G MíguezMichael Menzinger
Oct 4, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Patrick N McGraw, Michael Menzinger

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