Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb

Biochimica Et Biophysica Acta
John Zhong LiPeng Li

Abstract

Cideb, a member of CIDE family proteins, has emerged as an important regulator in the development of obesity and diabetes by controlling fatty acid synthesis and VLDL secretion in hepatocytes. Here, we investigated the role of Cideb in cholesterol biosynthesis, uptake and storage in the liver by using Cideb-null mice as a model system. Cideb-null mice and wild-type mice were treated with normal diet (ND) or high cholesterol diet (HCD) for one month. The metabolic parameters of cholesterol metabolism and expression profiles of genes in cholesterol biosynthesis and storage were measured. Cideb-null mice had lower levels of plasma cholesterol and LDL when fed with both ND and HCD and increased rate of cholesterol absorption. Furthermore, the liver of Cideb-null mice has lower rates of cholesterol biosynthesis and reduced expression levels of sterol response element-binding protein (SREBP) cleavage-activation protein (SCAP), and lower levels of nuclear form of SREBP2 and its downstream target genes in cholesterol biosynthesis pathway under a normal diet treatment. On the contrary, hepatic cholesterol biosynthesis rate between wild-type and Cideb-null mice was similar after high cholesterol diet treatment. Interestingly, hepatic cho...Continue Reading

Citations

May 25, 2013·Annual Review of Nutrition·Kelly V RugglesStephen L Sturley
Jul 2, 2014·The FEBS Journal·Ragunath SingaraveluJohn P Pezacki
Jul 28, 2016·Frontiers in Endocrinology·Yanping GaoZhan Yin
Apr 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Li XuPeng Li
Jul 18, 2019·Journal of Food Science·Rongrong LuZhuoqin Jiang
Apr 16, 2016·Molecular Medicine Reports·Janeesh Plakkal AyyappanYoung-Hwa Goo
Jun 7, 2017·Journal of Zhejiang University. Science. B·Yue-Qin QiuZong-Yong Jiang
May 23, 2021·Chemico-biological Interactions·George E BarretoAmirhossein Sahebkar

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