Control of choline oxidation by rat-liver mitochondria.

Biochimica Et Biophysica Acta
J J de Ridder, K van Dam

Abstract

The steady-state concentrations of choline and its reaction products in intact rat-liver mitochondria were determined under different conditions. From these measurements, it is concluded that in a sucrose medium choline dehydrogenation and betaine aldehyde dehydrogenation are the rate-limiting steps in overall choline oxidation under "State-3" or uncoupled conditions, respectively. Ageing of the mitochondria leads to changes in the mitochondrial membrane, resulting in a markedly different pattern of oxidation products. This finding explains why rotenone inhibits oxygen uptake with choline as substrate in fresh but not in aged mitochondria.

References

Jan 1, 1972·Archives of Biochemistry and Biophysics·L Smith, L Packer
Jan 26, 1973·Biochimica Et Biophysica Acta·J J De Ridder, K van Dam
Dec 14, 1973·Biochimica Et Biophysica Acta·J J de RidderK van Dam
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Citations

Jul 1, 1990·The Journal of Nutritional Biochemistry·S H Zeisel
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A D HansonD Rhodes
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amy R JohnsonSteven H Zeisel
Mar 15, 1979·Biochimica Et Biophysica Acta·J A Thompson, R C Reitz
Nov 9, 1976·Biochimica Et Biophysica Acta·J J de Ridder
Nov 26, 1984·Biochimica Et Biophysica Acta·M ZorattiV Petronilli
Jan 1, 1979·Progress in Lipid Research·R C Reitz

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