PMID: 2101473Sep 1, 1990Paper

Control of colonization by virulent Salmonella typhimurium by oral immunization of chickens with avirulent delta cya delta crp S. typhimurium

Research in Microbiology
J O Hassan, Roy Curtiss

Abstract

Oral immunization with a delta cya delta crp Salmonella typhimurium strain has been shown to preclude colonization by wild-type, virulent S. typhimurium and induces humoral and cellular immune response in chickens. Intestinal tract colonization by the virulent challenge strain was used to determine the level of protection conferred by immunization with the delta cya delta crp mutant. The associated humoral and cellular immune responses were measured by ELISA and delayed-type hypersensitivity (DTH) tests, respectively. The levels of colonization by both Salmonella strains were determined by enumeration of viable cells in the intestinal tract. A reduction in faecal excretion of the wild-type strain was observed with a single oral immunization with the delta cya delta crp mutant, but caecal colonization was not affected. However, double oral immunization with the delta cya delta crp mutant precludes caecal colonization by the virulent strain. IgM, IgA and IgG were detected against sonicated Salmonella whole-cell antigens. Outer membrane and flagella proteins induced DTH responses, whereas lipopolysaccharide failed to do so. The effectiveness of the delta cya delta crp strain in reducing caecal colonization by the highly virulent c...Continue Reading

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Citations

Nov 1, 1993·Veterinary Microbiology·R CurtissJ O Hassan
Jan 1, 2003·Veterinary Immunology and Immunopathology·U BabuR B Raybourne
Nov 1, 1996·Veterinary Immunology and Immunopathology·R Curtiss, J O Hassan
Aug 11, 1992·Current Opinion in Immunology·N ConnellW R Jacobs
Jan 1, 1994·International Journal of Technology Assessment in Health Care·J J Mekalanos
Nov 15, 2001·Animal Health Research Reviews·E P LillehojH S Lillehoj
Oct 12, 2013·Diseases of Aquatic Organisms·Lingyu GuanRoy Curtiss
Jul 25, 2012·International Journal of Food Microbiology·Gabriela Lopez-VelascoTrevor V Suslow
Aug 22, 2015·Avian Diseases·Arindam MitraKenneth L Roland
Mar 13, 2001·The Veterinary Journal·P MastroeniG Dougan
Apr 19, 2012·PLoS Pathogens·Douglas M HeithoffMichael J Mahan
Jun 5, 2004·Comparative Immunology, Microbiology and Infectious Diseases·Angela Berndt, Ulrich Methner
May 29, 2014·Infection and Immunity·Javier SantanderRoy Curtiss
Jun 6, 2008·Plant Molecular Biology·M Lucrecia AlvarezGuy A Cardineau
Aug 8, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Eric J BaitchmanHayley W Murphy
Aug 15, 2017·Journal of Food Protection·Mengyi Hu, Joshua B Gurtler
Apr 6, 2006·Animal Health Research Reviews·J RiceP Shewen

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