PMID: 9182798May 1, 1997Paper

Control of dopamine release in the retina: a transgenic approach to neural networks

Neuron
S GustincichE Raviola

Abstract

Dopaminergic, interplexiform amacrines (DA cells) were labeled in transgenic mice with human placental alkaline phosphatase, an enzyme that resides on the outer surface of the cell membrane. It was therefore possible to investigate their activity in vitro after dissociation of the retina with whole-cell current and voltage clamp, as well as their connections in the intact retina with the electron microscope. DA cells generate action potentials even in the absence of synaptic inputs. This activity is abolished by the amacrine cell transmitters GABA and glycine, which induce an inward current carried by chloride ions, and is stimulated by kainate, an agonist at the receptor for the bipolar cell transmitter glutamate, which opens nonselective cation channels. Since DA cells are postsynaptic to amacrine and bipolar cells, we suggest that the spontaneous discharge of DA cells is inhibited in the dark by GABAergic amacrines that receive their input from off-bipolars. Upon illumination, the GABA-inhibition is removed, DA cells generate action potentials, and their firing is modulated by the excitation received from on-bipolars.

References

Jul 15, 1978·The Journal of Comparative Neurology·J E Dowling, B Ehinger
Feb 1, 1992·Neurochemistry International·M B Djamgoz, H J Wagner
Nov 8, 1992·The Journal of Comparative Neurology·E StrettoiR F Dacheux
Mar 1, 1990·Trends in Neurosciences·N W DawW J Brunken
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S C Fields-BerryC L Cepko
Nov 15, 1990·The Journal of Comparative Neurology·D M Dacey
Jun 1, 1990·Journal of Neurocytology·H KolbL Dekorver
Oct 1, 1988·The Journal of Comparative Neurology·A P Mariani, J N Hokoc
Mar 22, 1985·The Journal of Comparative Neurology·R G Pourcho, D J Goebel
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W KamW J Rutter
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J PriceC Cepko
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J BergerS Udenfriend
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E M Lasater, J E Dowling
Oct 14, 1969·Annals of the New York Academy of Sciences·S PosenP K Saini
Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·B BauerL Aberg
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Dec 2, 1982·Brain Research·R G Pourcho
Jan 29, 1981·European Journal of Pharmacology·C W Kamp, W W Morgan
Dec 15, 1994·European Journal of Pharmacology·A Feigenspan, J Bormann
Mar 8, 1990·The Journal of Comparative Neurology·M TauchiR H Masland

❮ Previous
Next ❯

Citations

Nov 5, 1998·The Journal of Comparative Neurology·N MengerH Wässle
Mar 4, 2000·The Journal of Comparative Neurology·S HeD I Vaney
Mar 29, 2002·The Journal of Comparative Neurology·Enrica Strettoi, Maila Volpini
Feb 22, 2012·Cell and Tissue Research·Krisztina SzabadfiRobert Gabriel
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Aug 11, 2000·Journal of Chemical Neuroanatomy·P WitkovskyE Meller
Aug 15, 2001·Current Opinion in Neurobiology·R H Masland
Nov 5, 2002·Current Opinion in Chemical Biology·Kevin P TroyerR Mark Wightman
Mar 1, 2005·Visual Neuroscience·Jianguo XiaoDavid Marshak
Aug 23, 2007·Visual Neuroscience·Viktória DénesWilliam J Brunken
Aug 21, 2007·Visual Neuroscience·Ronald DorenbosElio Raviola
Oct 19, 2010·Visual Neuroscience·Ulrike GrünertDung Than Nguyen
Mar 15, 2012·Visual Neuroscience·Richard H Masland
Feb 9, 2012·Visual Neuroscience·Chi Zhang, Maureen A McCall
Jun 14, 2001·The European Journal of Neuroscience·M Z GuimarãesF G De Mello
Jan 23, 2008·Chemical Senses·Angela Pignatelli, Ottorino Belluzzi
Jul 15, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Wendy W HarrisonVictor E Malinovsky
Jul 17, 2004·Neuroreport·Dao-Qi ZhangDouglas G McMahon
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·K-F StorchC J Weitz
Jun 9, 2000·Annual Review of Neuroscience·R H Masland, E Raviola
Oct 25, 2006·Annual Review of Physiology·Stephen A Baccus
May 1, 2009·Journal of Neurophysiology·Hajime HirasawaElio Raviola
Feb 19, 2013·PloS One·Angela PignatelliOttorino Belluzzi
Sep 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hajime HirasawaElio Raviola
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haisong Jiang, Mengqing Xiang
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuki HayashidaAndrew T Ishida
Apr 15, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E Popova
Jan 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Massimo Contini, Elio Raviola
Mar 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stefano GustincichElio Raviola
Dec 14, 2004·The Journal of Comparative Neurology·Paul WitkovskyKonrad Kohler
Mar 10, 2001·Nature·P A LeightonM Tessier-Lavigne
Aug 31, 2001·Nature Neuroscience·R H Masland
Aug 15, 2014·Experimental Neurology·Lais Takata WalterAlexandre Hiroaki Kihara
Sep 12, 2015·The Journal of Comparative Neurology·Elena IvanovaBotir T Sagdullaev
Sep 16, 2004·The Journal of Comparative Neurology·Yen-Hong KaoNoga Vardi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.