Control of energy metabolism by glucagon and adrenaline in perfused rat liver

FEBS Letters
S Soboll, R Scholz

Abstract

Changes in subcellular distribution of adenine nucleotides, mitochondrial/cytosolic proton gradients, rates of respiration, gluconeogenesis (fasted state) and glycogenolysis (fed state) were studied in isolated perfused rat livers following addition of glucagon (10(-8) M) or adrenaline (10(-7) M). Glucagon increased the gradient in all states. The cytosolic ATP/ADP ratio was increased in the fasted but decreased in the fed state which is consistent with a diminished futile cycling in gluconeogenesis (fasted state) or a decreased glycolytic rate (fed state). Adrenaline caused an increase in the proton gradient and the mitochondrial ATP/ADP ratio. The two effects are attributed to increased calcium entry into the matrix space.

References

Mar 1, 1985·The American Journal of Physiology·J R WilliamsonA P Thomas
Mar 3, 1986·European Journal of Biochemistry·W M TaylorF L Bygrave
Jan 1, 1985·Annual Review of Biochemistry·L E Hokin
Feb 29, 1984·Biochemical and Biophysical Research Communications·S KimuraE Ogata
Jan 1, 1980·Advances in Experimental Medicine and Biology·R Scholz, U Schwabe

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Citations

Dec 1, 1991·Journal of Bioenergetics and Biomembranes·R G Hansford
Dec 1, 1995·Journal of Bioenergetics and Biomembranes·S Soboll
Feb 1, 1990·The Proceedings of the Nutrition Society·J G McCormack, R M Denton
Sep 2, 1998·The EMBO Journal·L D Robb-GaspersA P Thomas
Nov 8, 2013·International Journal of Molecular Sciences·Andrea Luiza de OliveiraAdelar Bracht
Jul 1, 1991·Archives of Biochemistry and Biophysics·P J ThomasJ A Thomas
Jan 24, 2007·Physiological Reviews·Jorgina SatrústeguiAraceli Del Arco
May 3, 2006·Molecular and Cellular Biochemistry·Adriana G MartinsAdelar Bracht

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