Control of entropy in neural models of environmental state.

ELife
Timothy H MullerJill X O'Reilly

Abstract

Humans and animals construct internal models of their environment in order to select appropriate courses of action. The representation of uncertainty about the current state of the environment is a key feature of these models that controls the rate of learning as well as directly affecting choice behaviour. To maintain flexibility, given that uncertainty naturally decreases over time, most theoretical inference models include a dedicated mechanism to drive up model uncertainty. Here we probe the long-standing hypothesis that noradrenaline is involved in determining the uncertainty, or entropy, and thus flexibility, of neural models. Pupil diameter, which indexes neuromodulatory state including noradrenaline release, predicted increases (but not decreases) in entropy in a neural state model encoded in human medial orbitofrontal cortex, as measured using multivariate functional MRI. Activity in anterior cingulate cortex predicted pupil diameter. These results provide evidence for top-down, neuromodulatory control of entropy in neural state models.

Associated Datasets

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Citations

May 11, 2019·ELife·Philipp SchwartenbeckKarl J Friston
Dec 19, 2019·ELife·Jennifer L CookRoshan Cools
May 19, 2020·ELife·Alexandre Ls FilipowiczJoshua I Gold
Nov 9, 2019·PLoS Computational Biology·R Becket EbitzBenjamin Y Hayden
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Daniele CaligioreGianluca Baldassarre
Sep 19, 2020·Nature Reviews. Neuroscience·Gina R PoeSusan J Sara
Oct 20, 2020·ELife·Chang-Hao KaoJoseph W Kable
Dec 1, 2020·PLoS Biology·R Becket EbitzBenjamin Y Hayden
Nov 14, 2020·NeuroImage·Valeria OlivaJonathan C W Brooks
Jul 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roshan Cools, Amy F T Arnsten
Aug 21, 2021·Neuron·R Becket Ebitz, Benjamin Y Hayden
Nov 20, 2021·ELife·Cathy S ChenNicola M Grissom

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Methods Mentioned

BETA
PCA

Software Mentioned

FEAT
FMRIB Linear Non Linear Registration Tool FLIRT FNIRT
FMRIB Software Library ( FSL
mOFC
fMRI Expert Analysis Tool ( FEAT )
Medial

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