PMID: 6163088Mar 19, 1981Paper

Control of enzyme secretion by non-cholinergic, non-adrenergic nerves in guinea pig pancreas

Nature
G T PearsonO H Petersen

Abstract

Depolarization of pancreatic cells by exposure to high potassium solutions is associated with release of amylase. In the guinea pig, but not the mouse or cat, this Ca-dependent amylase secretion is resistant to atropine blockade, thus Scheele and Haymovits concluded that the enzyme secretion evoked by K depolarization does not involve release of transmitter from intrapancreatic nerves but is a consequence of Ca uptake into acinar cells mediated by the membrane depolarization. This hypothesis is inconsistent with current concepts of stimulus--secretion coupling in electrically non-excitable cells. The observation of Scheele and Haymovits could, however, also be explained by the release of a non-cholinergic, secretomotor transmitter as a consequence of the depolarization of intrapancreatic nerves. By adapting the technique of electrical field stimulation of isolated pancreatic segments to our studies of amylase secretion, we have now been able to demonstrate both cholinergic and non-cholinergic, non-adrenergic secretomotor nerves in the guinea pig pancreas. Excitation of the non-cholinergic nerves stimulates amylase secretion by a different intracellular coupling mechanism from that activated by cholinergic nerves or by peptides ...Continue Reading

References

Jul 1, 1976·Physiological Reviews·O H Petersen
Apr 28, 1978·Annals of the New York Academy of Sciences·G A Scheele, A Haymovits
Apr 28, 1978·Annals of the New York Academy of Sciences·O H Peterson, N Iwatsuki
Mar 2, 1978·Histochemistry·F SundlerO Schaffalitzky de Muckadell
Mar 1, 1978·Life Sciences·L I LarssonO B Schaffalitzky de Muckadell
Mar 1, 1974·Analytical Biochemistry·E K MatthewsJ A Williams

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Citations

Jan 1, 1983·Pflügers Archiv : European journal of physiology·O H Petersen, Y Maruyama
Jan 1, 1984·Pflügers Archiv : European journal of physiology·G T Pearson, O H Petersen
Mar 20, 1998·Comparative Biochemistry and Physiology. Part A, Physiology·G E Boeckxstaens, P A Pelckmans
Oct 20, 1982·Biochimica Et Biophysica Acta·O H Petersen
Feb 10, 2018·The Journal of Physiology·Oleksiy GryshchenkoOle H Petersen
Jul 18, 1981·British Medical Journal·G M Lees
May 6, 2021·Physiological Reviews·Ole H PetersenShuang Peng

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