Control of erythropoiesis after high altitude acclimatization

European Journal of Applied Physiology
G SavoureyJean-Marie Cottet-Emard

Abstract

Erythropoiesis was studied in 11 subjects submitted to a 4-h hypoxia (HH) in a hypobaric chamber (4,500 m, barometric pressure 58.9 kPa) both before and after a 3-week sojourn in the Andes. On return to sea level, increased red blood cells (+3.27%), packed cell volume (+4.76%), haemoglobin (+6.55%) ( P<0.05), and increased arterial partial pressure of oxygen (+8.56%), arterial oxygen saturation (+7.40%) and arterial oxygen blood content ( C(a)O(2)) (+12.93%) at the end of HH ( P<0.05) attested high altitude acclimatization. Reticulocytes increased during HH after the sojourn only (+36.8% vs +17.9%, P<0.01) indicating a probable higher reticulocyte release and/or production despite decreased serum erythropoietin (EPO) concentrations (-46%, P<0.01). Hormones (thyroid, catecholamines and cortisol), iron status (serum iron, ferritin, transferrin and haptoglobin) and renal function (creatinine, renal, osmolar and free-water clearances) did not significantly vary (except for lower thyroid stimulating hormone at sea level, P<0.01). Levels of 2,3-diphosphoglycerate (2,3-DPG) increased throughout HH on return (+14.7%, P<0.05) and an inverse linear relationship was found between 2,3-DPG and EPO at the end of HH after the sojourn only ( r...Continue Reading

Citations

Nov 19, 2009·Journal of Anesthesia·Kay B Leissner, Feroze U Mahmood
Oct 24, 2008·International Journal of Hematology·Pierre SalletGabriel Baverel
Jul 27, 2007·Journal of Sports Sciences·Rosario AbellanJordi Segura
Oct 23, 2010·Journal of Applied Physiology·Britt ChristensenJohn J Kopchick
Jun 3, 2015·Pakistan Journal of Biological Sciences : PJBS·Yones HematyMonir Doudi
Feb 28, 2015·Military Medical Research·Xiao-Han DingLan Huang
Sep 25, 2009·High Altitude Medicine & Biology·Santiago EstevaGinés Viscor
Dec 21, 2010·Wilderness & Environmental Medicine·Santiago EstevaGinés Viscor
May 1, 2007·Respiratory Physiology & Neurobiology·H-C GungaW Schobersberger
Jul 31, 2013·Respiratory Physiology & Neurobiology·Meaghan J MacNuttA William Sheel
Jul 26, 2014·Diabetes Care·Pieter de MolCees J Tack
May 6, 2016·Frontiers in Physiology·Jonas J SaugyGrégoire P Millet
May 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Michele FerrariWarren M Zapol
Aug 5, 2006·Medicine and Science in Sports and Exercise·Rémi MounierNicole Fellmann
May 8, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Mathieu GautierVeronique Eder
Jun 18, 2017·Frontiers in Physiology·Stefan De SmetPeter Hespel
Nov 12, 2015·Frontiers in Neuroscience·Elena Rybnikova, Mikhail Samoilov
Dec 19, 2018·Orthopaedic Journal of Sports Medicine·James G ConnollyTanvir Choudhri
Jul 3, 2021·Frontiers in Physiology·Kamila PłoszczycaMarcin Baranowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved