Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor. Case report.

Journal of Neurosurgery
J Watterson, J R Priest

Abstract

Primary intracranial germ-cell tumors are infrequently occurring neoplasms which most often arise in the pineal or sellar regions. Germinomas are seen more frequently than nongerminomatous germ-cell tumors; they are often curable with radiotherapeutic approaches, or with chemotherapy in the rare instance of extraneural metastasis. Nongerminomatous germ-cell tumors are relatively radioresistant and when extraneural metastasis has occurred, they have been fatal in all of the 32 previously reported cases. The case of a 14-year-old girl with a mixed malignant germ-cell tumor arising in the pineal region is reported. Extraneural metastasis to the lung developed 12 months after whole-brain radiotherapy was completed. She was treated with etoposide (VP-16), high-dose cisplatin, vinblastine, and bleomycin and is currently without evidence of disease 46 months postmetastasis.

References

Dec 1, 1979·Journal of Clinical Ultrasound : JCU·A Goldstein, L N Langrill
May 1, 1988·Journal of Neurosurgery·M S EdwardsW M Wara
Jun 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R F OzolsR C Young
Aug 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B J RothL H Einhorn
Aug 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N BorgeH H Lien
Aug 1, 1985·Journal of Neurosurgery·M T JenningsF Hochberg
Jan 1, 1985·Journal of Neuro-oncology·J C AllenR Walker
Aug 1, 1973·American Journal of Diseases of Children·S BordenC C Wang
Aug 1, 1966·Archives of Surgery·R H NishiyamaJ H Simrall
Nov 1, 1953·The Journal of Endocrinology·H ZONDEKH UNGER
Jul 1, 1965·The Journal of Pediatrics·L C EDMONDS, G M CARRERA
Mar 1, 1950·Journal of Neurosurgery·V N TOMPKINSE H CAMPBELL

❮ Previous
Next ❯

Citations

Sep 1, 1995·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·A IzumiharaM Hatano
Feb 27, 2003·Southern Medical Journal·Muhammad Wasif Saif, Chris H Takimoto
Mar 1, 1994·Neurosurgery·H D HerrmannF J Schulte
Mar 8, 2003·Acta Neuropathologica·Christian H Rickert

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.