PMID: 4905989Nov 1, 1969Paper

Control of fatty acid composition in phospholipids of Escherichia coli: response to fatty acid supplements in a fatty acid auxotroph

Proceedings of the National Academy of Sciences of the United States of America
M EsfahaniS J Wakil

Abstract

The effect of exogenous unsaturated fatty acids on the fatty acid composition of phospholipids of a mutant of E. coli has been examined. These exogenous acids serve as growth factors for an auxotroph requiring unsaturated fatty acids. When each member of a structurally homologous series of cis-unsaturated fatty acids serves as a growth factor, the percentage of unsaturated fatty acid present in phospholipids increases with increasing chain length or decreasing number of double bonds in the apolar chain of the supplement. At 37 degrees , trans-octadecenoic acids support growth and are incorporated into phospholipids at levels higher than the corresponding cis-acids. However, a temperature shift to 27 degrees with trans-acids results in loss of viability and lysis. Utilization of cis-acids as supplements at decreasing temperatures between 42 degrees and 27 degrees results in increasing amounts of unsaturated fatty acids in phospholipids with decreasing temperature. These observations suggest the operation of a regulatory mechanism which controls the composition of saturated versus unsaturated acids in order to maintain the physical properties of phospholipids within narrow limits.

References

Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·D F Silbert, P R Vagelos
Jul 14, 1966·Annals of the New York Academy of Sciences·L L van Deenen
Dec 7, 1966·Biochimica Et Biophysica Acta·L M van Golde, L L van Deenen
May 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·J M SteimR L Rader
Jan 14, 1968·Journal of Molecular Biology·D ChapmanS A Penkett
Jul 1, 1962·The Journal of Pharmacy and Pharmacology·L van DEENENE MULDER

❮ Previous
Next ❯

Citations

Nov 1, 1977·Biochimica Et Biophysica Acta·G LegalyE Stuke
Dec 22, 1999·Biochimica Et Biophysica Acta·W E Lands
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P OverathW Stoffel
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M EsfahaniS J Wakil
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·C J ScandellaH M McConnell
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J E Cronan
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G R GreenbergH G Khorana
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T K Ray, J E Cronan
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·R A LernerB F Cravatt
May 1, 1973·Antimicrobial Agents and Chemotherapy·I GoldbergK Bloch
Jul 1, 1973·Antimicrobial Agents and Chemotherapy·C A Plate
Oct 10, 1998·Molecular Microbiology·J E Cronan, S Subrahmanyam
Feb 14, 1972·Biochimica Et Biophysica Acta·J E Cronan, P R Vagelos
Mar 16, 1971·Biochimica Et Biophysica Acta·A MontfoortL L van Deenen
Feb 2, 1971·Biochimica Et Biophysica Acta·M P Carpenter
Jan 1, 1982·Archives of Oral Biology·R J CroutR H Connamacher
Feb 5, 1971·Biochemical and Biophysical Research Communications·B L AdamsJ Seckbach
Oct 23, 1972·Biochimica Et Biophysica Acta·C W HaestL L van Deenen
Aug 13, 1971·Biochimica Et Biophysica Acta·J Schwencke, N Magaña-Schwencke
Sep 20, 2012·Biochimica Et Biophysica Acta·Catherine Tardy-LaporteIsabelle Marcotte
Nov 5, 2016·Biochimica Et Biophysica Acta·Marwa LaadhariIsabelle Marcotte
Jul 1, 1974·FEBS Letters·L HuangA Haug

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.