Control of fatty acid metabolism. I. Induction of the enzymes of fatty acid oxidation in Escherichia coli.

Journal of Bacteriology
G WeeksS J Wakil

Abstract

Escherichia coli grows on long-chain fatty acids after a distinct lag phase. Cells, preadapted to palmitate, grow immediately on fatty acids, indicating that fatty acid oxidation in this bacterium is an inducible system. This hypothesis is supported by the fact that cells grown on palmitate oxidize fatty acids at rates 7 times faster than cells grown on amino acids and 60 times faster than cells grown on a combined medium of glucose and amino acids. The inhibitory effect of glucose may be explained in terms of catabolite repression. The activities of the five key enzymes of beta-oxidation [palmityl-coenzyme A (CoA) synthetase, acyl-CoA dehydrogenase, enoyl-CoA hydrase, beta-hydroxyacyl-CoA dehydrogenase, and thiolase] all vary coordinately over a wide range of activity, indicating that they are all under unit control. The ability of a fatty acid to induce the enzymes of beta-oxidation and support-growth is a function of its chain length. Fatty acids of carbon chain lengths of C(14) and longer induce the enzymes of fatty acid oxidation and readily support growth, whereas decanoate and laurate do not induce the enzymes of fatty acid oxidation and only support limited growth of palmitate-induced cells. Two mutants, D-1 and D-3, wh...Continue Reading

References

Oct 11, 1967·Biochemical and Biophysical Research Communications·P Overath, E M Raufuss
Jan 1, 1966·Cold Spring Harbor Symposia on Quantitative Biology·D Sheppard, E Englesberg
Sep 1, 1953·Biochimica Et Biophysica Acta·F LYNEN, S OCHOA
Jul 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·S J WAKILF SAUER
Jun 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·P W MAJERUSP R VAGELOS
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·B MAGASANIK

❮ Previous
Next ❯

Citations

Feb 1, 1970·European Journal of Biochemistry·D SamuelG Ailhaud
Sep 13, 1971·European Journal of Biochemistry·E VanderwinkelJ Vande Meerssche
Oct 10, 1998·Molecular Microbiology·J E Cronan, S Subrahmanyam
May 31, 2020·The Journal of Biological Chemistry·Krista M ArmbrusterTimothy C Meredith
Apr 27, 1978·Archives of Microbiology·C M RobertsJ R Sokatch
Apr 30, 1975·Molecular and Cellular Biochemistry·V A Tol
Sep 25, 1972·European Journal of Biochemistry·G Pauli, P Overath
Jan 19, 1999·Annual Review of Microbiology·A J Cozzone
Nov 23, 2006·Nature Biotechnology·Chetan BettegowdaShibin Zhou
Feb 5, 2015·The Journal of Biological Chemistry·Jiangwei Yao, Charles O Rock
Sep 7, 2004·The Journal of Biological Chemistry·Concetta C Dirusso, Paul N Black
Jun 9, 2020·Biochemical and Biophysical Research Communications·Yustina YusufTatsuo Kurihara
Mar 1, 1997·Progress in Lipid Research·P A Watkins
Mar 1, 1976·Bacteriological Reviews·L K MasseyR S Conrad
Aug 1, 1972·Journal of Bacteriology·C W Sheu, E Freese
May 1, 1983·Journal of Bacteriology·W D NunnJ E Cronan
Apr 1, 1973·Journal of Bacteriology·R Calmes, S J Deal
Nov 1, 1971·Journal of Bacteriology·J P Salanitro, W S Wegener
Nov 1, 1971·Journal of Bacteriology·J P Salanitro, W S Wegener
Oct 1, 1987·Applied and Environmental Microbiology·A BeaubienC Jolicoeur
Jan 1, 1983·Journal of Bacteriology·B J MonclaW T Charnetzky
Apr 1, 1992·Applied and Environmental Microbiology·S SlaterD Dennis
Jun 26, 1974·Biochimica Et Biophysica Acta·A AudetP Proulx
Sep 1, 1971·Biochimica Et Biophysica Acta·E Pugh, J B Sidbury
Dec 31, 2005·Journal of Bacteriology·Surtaj Hussain Iram, John E Cronan
Oct 1, 1986·Journal of Bacteriology·M O'ConnellL Shapiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.