Control of firing by small (S)-alpha-amino-3-hydroxy-5-methyl-isoxazolepropionic acid-like inputs in hypothalamic gonadotropin releasing-hormone (GnRH) neurons

Neuroscience
Kelly J Suter

Abstract

Episodic release of gonadotropin releasing hormone (GnRH) is obligatory for mammalian reproduction. The contribution of synaptic input to intermittent firing of GnRH neurons is unclear. GnRH neurons have very few synapses and most post-synaptic currents are small. Therefore, the impact of synaptic currents on firing in GnRH neurons was directly examined using simulated (S)-alpha-amino-3-hydroxy-5-methyl-isoxazolepropionic acid (AMPA)-like inputs applied with the method of dynamic current clamping. Tightly synchronized inputs and 50 ms bursts of excitatory input resulted in action potentials that were coincident with the stimulus. Neither input pattern resulted in sustained firing. When ongoing patterns of simulated inputs were applied over a range of parameters, action potentials were associated with clusters of AMPA-like inputs of 250 pS (approximately 15 pA amplitudes), while single inputs of 500 pS (approximately 30 pA amplitudes) resulted in action potentials. Ongoing inputs of 500 pS drove firing at 4-9 Hz. These findings provide evidence that small, simulated glutamatergic inputs can control firing in GnRH neurons and suggest that despite the small amplitudes, endogenous synaptic input mediated by glutamate may contribute...Continue Reading

References

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Citations

Jun 15, 2011·Journal of Computational Neuroscience·Dávid CsercsikZsolt Liposits
Sep 8, 2010·Brain Research·Oline K RønnekleivChunguang Zhang
Jan 29, 2013·Nature Neuroscience·Alejandro LomnicziSergio R Ojeda
Mar 20, 2010·Endocrine Reviews·Catherine A Christian, Suzanne M Moenter
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhiguo ChuSuzanne M Moenter
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peilin Chen, Suzanne M Moenter
Jun 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J HemondKelly J Suter
May 20, 2011·Journal of Neuroendocrinology·O K RønnekleivC Zhang
Sep 3, 2010·Brain Research·Karl J IremongerAllan E Herbison
Oct 6, 2010·Brain Research·Suzanne M Moenter
Jun 20, 2006·Molecular and Cellular Endocrinology·Jenny Clarkson, Allan E Herbison
Nov 1, 2008·Integrative and Comparative Biology·Carson B Roberts, Kelly J Suter
Aug 27, 2005·Endocrinology·Suzanne M Moenter, R Anthony DeFazio

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