Control of fluid intake by estrogens in the female rat: role of the hypothalamus

Frontiers in Systems Neuroscience
Jessica Santollo, Derek Daniels

Abstract

Body fluid homeostasis is maintained by a complex network of central and peripheral systems that regulate blood pressure, fluid and electrolyte excretion, and fluid intake. The behavioral components, which include well regulated water and saline intake, are influenced by a number of hormones and neuropeptides. Since the early 1970s, it has been known that the ovarian estrogens play an important role in regulating fluid intake in females by decreasing water and saline intake under a variety of hypovolemic conditions. Behavioral, electrophysiological, gene and protein expression studies have identified nuclei in the hypothalamus, along with nearby forebrain structures such as the subfornical organ (SFO), as sites of action involved in mediating these effects of estrogens and, importantly, all of these brain areas are rich with estrogen receptors (ERs). This review will discuss the multiple ER subtypes, found both in the cell nucleus and associated with the plasma membrane, that provide diversity in the mechanism through which estrogens can induce behavioral changes in fluid intake. We then focus on the relevant brain structures, hypothesized circuits, and various peptides, such as angiotensin, oxytocin, and vasopressin, implicate...Continue Reading

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Citations

Jun 21, 2015·Hormones and Behavior·Jessica Santollo, Derek Daniels
Sep 24, 2016·Journal of Neurosurgery·Harrison KimIrshad H Chaudry
Jun 3, 2017·Hormones and Behavior·Jessica SantolloDerek Daniels
Jul 18, 2017·Experimental Physiology·Jessica Santollo
Jun 18, 2020·Journal of Toxicology and Environmental Health. Part a·Gwyndolin M VailTroy A Roepke
Apr 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica SantolloDerek Daniels
Nov 25, 2020·Physiology & Behavior·Jessica Santollo, Andrea A Edwards
May 22, 2021·Hormones and Behavior·Jessica SantolloKatherine E Myers

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