Control of fungal sterol C-24 transalkylation: importance to developmental regulation

Biochemical and Biophysical Research Communications
W David NesE J Parish

Abstract

When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.

References

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Citations

Aug 30, 2003·Phytochemistry·W David Nes
Jan 1, 1989·Journal of Enzyme Inhibition·D Berg, M Plempel
Oct 29, 1998·FEMS Immunology and Medical Microbiology·E S Kaneshiro
Jul 1, 1999·Bioorganic & Medicinal Chemistry Letters·P BeuchetY Letourneux
Feb 11, 1998·Clinical Microbiology Reviews·E S Kaneshiro
Dec 1, 1993·Applied and Environmental Microbiology·G A Muñoz, E Agosin
Jan 1, 1993·Progress in Lipid Research·E I Mercer
Aug 1, 1989·Archives of Biochemistry and Biophysics·W D NesE J Parish

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