Control of glycogen metabolism by insulin in isolated hepatocytes

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
A C Beynen, M J Geelen

Abstract

Isolated rat hepatocytes incubated in a simple bicarbonate buffer, previously shown to display enhanced rates of fatty acid biosynthesis upon a brief exposure to insulin, were used to study acute effects of this hormone on glycogen metabolism. In hepatocytes prepared from fed rats insulin does not increase glycogen deposition as measured chemically, but the incorporation of labelled glucose is markedly accelerated. The rate of disappearance of radioactivity from glycogen, prelabelled with D[U-14C]glucose, is lowered by insulin. In hepatocytes from starved rats insulin promotes net glycogen synthesis. All metabolic parameters studied are affected by glucagon in manner opposite to that of insulin.

Citations

Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·C OttolenghiL Brighenti
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·E PlisetskayaA Gorbman
Jan 24, 2002·Journal of Hepatology·Corinne LangLukas Krähenbühl
Jun 1, 1984·Metabolism: Clinical and Experimental·M B Davidson
Sep 1, 1983·European Journal of Biochemistry·I Probst, K Jungermann
Mar 26, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Lukas KrähenbühlStephan Krähenbühl

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