PMID: 9182824Jun 1, 1997Paper

Control of hair growth with parathyroid hormone (7-34)

The Journal of Investigative Dermatology
M B SchilliM F Holick

Abstract

Parathyroid hormone (PTH) related peptide (PTHrP) is thought to influence the proliferation and differentiation of the epidermis and hair follicle. As a means of elucidating the biologic function of PTHrP on the hair follicle, a PTHrP analog PTH (7-34), which is a PTH/PTHrP receptor antagonist, was given intraperitoneally twice daily to C57 BL/6 mice at different stages of the hair cycle. PTH (7-34) induced 99 +/- 4.5% (mean +/- SEM) of resting telogen hair follicles into a proliferative (anagen) state, whereas 100% of the hair follicles in the control group remained in telogen. To determine whether this peptide influenced the progression of the hair follicles from anagen to catagen (hair follicle maturation and regression), groups of mice that were either spontaneously in or induced to anagen received either PTH (7-34) or placebo. Morphometric analysis of the hair follicles from the middle back region of the spontaneous anagen mice that received PTH (7-34) revealed that 19 +/- 4% (mean +/- SEM) of the follicles were in anagen VI, whereas none (0%) were in anagen in the control group. Similarly, in induced anagen mice treated with PTH (7-34), 22.3 +/- 1.4 (mean +/- SEM) of the follicles were in anagen VI compared to only 1.3 +/...Continue Reading

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Citations

Mar 22, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S Müller-RöverR Paus
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Vincent DuheronChristopher G Mueller
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
Mar 11, 2005·Expert Opinion on Investigational Drugs·Georgann A Poulos, Paradi Mirmirani
Apr 25, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y-Y LeeJ-S Hwang
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevA R Paus
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K FoitzikR Paus
Sep 19, 2020·Experimental Dermatology·Stefanie Heilmann-HeimbachMarkus M Nöthen
Aug 10, 1999·Experimental Dermatology·K S Stenn, R Paus
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevR Paus
Sep 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Masashi OkadaRyotaro Yoshida
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Dec 25, 2004·Differentiation; Research in Biological Diversity·Ralf Paus, Kerstin Foitzik
May 6, 2006·The Journal of Investigative Dermatology·A Godwin DiamondJohn Foley

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