Abstract
We tested whether patients presenting with atrial fibrillation (AF) or flutter (AFl) with a rapid ventricular response could maintain control of heart rate while transferring from a bolus and continuous infusion of intravenous diltiazem to oral diltiazem. Forty patients with AF or AFI and sustained ventricular rate > or = 120 beats/min received intravenous diltiazem "bolus" (20 to 25 mg for 2 minutes) and "infusion" (5 to 15 mg/hour for 6 to 20 hours). Oral long-acting diltiazem (diltiazem CD 180, 300, or 360 mg/24 hours) was administered in patients in whom stable heart rate control was attained during constant infusion. Intravenous diltiazem infusion was discontinued 4 hours after the first oral dose, and patients were monitored during 48 subsequent hours of "transition" to oral therapy. Response to diltiazem was defined as heart rate <100 beats/min, > or = 20% decrease in heart rate from baseline, or conversion to sinus rhythm. Other rate control or antiarrhythmic medications were not allowed during the study period. Thirty-seven of 40 patients maintained heart rate control during the bolus, and 35 of the remaining 37 maintained control during the infusion of intravenous diltiazem. Of the 35 patients achieving heart rate con...Continue Reading
References
Dec 1, 1979·The American Journal of Cardiology·D DavidE Kaplinsky
Jun 4, 1992·The American Journal of Cardiology·B H Sarter, F E Marchlinski
Nov 12, 1992·The New England Journal of Medicine·M D EzekowitzM J Radford
Nov 1, 1992·Circulation·V C DiasK A Ellenbogen
Aug 1, 1991·Journal of the American College of Cardiology·S J ConnollyC Joyner
Oct 1, 1991·Journal of the American College of Cardiology·K A EllenbogenD M Mirvis
Apr 1, 1991·Annals of Internal Medicine·R H Falk, J I Leavitt
Apr 1, 1991·Chest·E GalunM Eliakim
Nov 29, 1990·The New England Journal of Medicine·UNKNOWN Boston Area Anticoagulation Trial for Atrial Fibrillation InvestigatorsJ Philip Kistler
Jul 1, 1990·Journal of the American College of Cardiology·T Lundström, L Rydén
Jan 28, 1989·Lancet·P PetersenB Andersen
May 1, 1989·The American Journal of Cardiology·D M SalernoL V Giorgi
Mar 1, 1989·Journal of the American College of Cardiology·E C HuyckeE V Platia
Jan 1, 1988·Chest·J E AtwoodV F Froelicher
Feb 1, 1986·Circulation·A RothU Elkayam
Oct 1, 1984·American Heart Journal·R DiBiancoA Y Olukotun
Jan 1, 1982·American Heart Journal·L B MitchellJ W Mason
Jun 1, 1982·Circulation·J B SchwartzD C Harrison
Nov 1, 1994·The American Journal of Cardiology·I F GoldenbergW R Pedersen
Citations
Feb 28, 2002·Lancet·Nicholas S PetersVias Markides
Sep 27, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Richard L PageSana M Al-Khatib
Sep 27, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Richard L PageSana M Al-Khatib
Sep 27, 2015·Journal of the American College of Cardiology·Richard L PageSana M Al-Khatib
Sep 27, 2015·Journal of the American College of Cardiology·Richard L PageSana M Al-Khatib
Jul 28, 2016·The Journal of Emergency Medicine·Adam L RossMichelle A Krawczynski
Sep 25, 2015·Circulation·Richard L PageUNKNOWN Evidence Review Committee Chair‡
Sep 25, 2015·Circulation·Richard L PageUNKNOWN Evidence Review Committee Chair‡
Sep 11, 2019·European Heart Journal·Josep BrugadaUNKNOWN ESC Scientific Document Group